Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Emilio LamazaresBiotecnology and Biopharmaceuticals Laboratory, Departamento de Fisiopatología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, P.O. Box 160-C, Concepción 4030000, Chile.
Aleikar VásquezBiotecnology and Biopharmaceuticals Laboratory, Departamento de Fisiopatología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, P.O. Box 160-C, Concepción 4030000, Chile.ORCID 0000-0001-6717-3967
Kelly GancinoGrupo de Investigación en Sanidad Animal y Humana (GISAH), Departamento de Ciencias de la Vida y la Agricultura, Universidad de las Fuerzas Armadas ESPE, Sangolquí 171103, Ecuador.ORCID 0009-0007-7799-468X
Felipe SandovalBiotecnology and Biopharmaceuticals Laboratory, Departamento de Fisiopatología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, P.O. Box 160-C, Concepción 4030000, Chile.
Javiera Yáñez-TorresBiotecnology and Biopharmaceuticals Laboratory, Departamento de Fisiopatología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, P.O. Box 160-C, Concepción 4030000, Chile.
Miguel A Gutierrez-ReinosoFacultad de Ciencias Agropecuarias y Recursos Naturales, Carrera de Medicina Veterinaria, Universidad Técnica de Cotopaxi (UTC), Latacunga 050150, Ecuador.
Manuel García-HerrerosInstituto Nacional de Investigação Agrária e Veterinária (INIAV), 2005-424 Santarém, Portugal.ORCID 0000-0002-0911-6689
Paula GädickePathology and Preventive Medicine Department, School of Veterinary Sciences, Universidad de Concepción, Avenida Vicente Méndez 595, P.O. Box 537, Chillán 3812120, Chile.ORCID 0000-0001-6915-1446
Ignacio CabezasClinical Science Department, School of Veterinary Sciences, Universidad de Concepción, Avenida Vicente Méndez 595, P.O. Box 537, Chillán 3812120, Chile.ORCID 0000-0001-8118-2579
Florence HuguesClinical Science Department, School of Veterinary Sciences, Universidad de Concepción, Avenida Vicente Méndez 595, P.O. Box 537, Chillán 3812120, Chile.ORCID 0000-0002-2283-6269
Thelvia I RamosGrupo de Investigación en Sanidad Animal y Humana (GISAH), Departamento de Ciencias de la Vida y la Agricultura, Universidad de las Fuerzas Armadas ESPE, Sangolquí 171103, Ecuador.ORCID 0000-0002-0584-6166
Frank CamachoRecombinant Biopharmaceuticals Laboratory, Departamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, P.O. Box 160-C, Concepción 4030000, Chile.
Karel Mena-UleciaDepartamento de Ciencias Biológicas y Químicas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Ave. Rudecindo Ortega #02950, Temuco 4780000, Chile.ORCID 0000-0001-6651-511X
Jorge R ToledoBiotecnology and Biopharmaceuticals Laboratory, Departamento de Fisiopatología, Facultad de Ciencias Biológicas, Universidad de Concepción, Víctor Lamas 1290, P.O. Box 160-C, Concepción 4030000, Chile.ORCID 0000-0002-9879-7710
Funding
Agencia Nacional de Investigación y Desarrollo (ANID), Chile. Fondef ID23I10082
6 · The paper itself
Abstract
Early embryonic loss is a major cause of reproductive inefficiency in cattle, primarily due to premature luteolysis. Interferon tau (IFN-τ), secreted by the trophoblast, plays a critical role in maternal recognition of pregnancy by maintaining corpus luteum function. However, its practical application has been limited by its rapid degradation and short half-life in vivo. Here, we developed a novel formulation of recombinant bovine IFN-τ, combining chitosan-based microencapsulation with starch-chitosan hydrogel delivery, enabling sustained intrauterine release. This dual-delivery strategy offers a significant improvement over conventional IFN-τ administration methods that rely on repeated intrauterine infusions of soluble protein. The rbIFN-τ was expressed in
Indexed as
Interferon Type ILuteolysisPregnancy ProteinsAnimalsCattleChitosanDrug CompoundingFemaleMolecular Docking SimulationPregnancyProgesteroneRecombinant ProteinsChitosaninterferon tauInterferon Type IPregnancy ProteinsProgesteroneRecombinant Proteinsinterferon tauluteolysis modulationmicroencapsulation
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A Novel Microencapsulated Bovine Recombinant Interferon Tau Formulation for Luteolysis Modulation in Cattle. · full record | OpenQuestion