Platinum Nanoparticles Loaded in Polydopamine-Modified Porous Coordination Network-224 with Peroxidase-Like Activity for Sensitive Glutathione Detection.

Shoubei Gao, Mingyue Gao, Chenran Zhen, Yanshuai Cui, Xianbing Ji, Ruyu Li, Longgang Wang

Abstract read

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Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Shoubei GaoHebei Key Laboratory of Agroecological Safety, Department of Environmental Engineering, Hebei University of Environmental Engineering, Qinhuangdao 066102, China.

Mingyue GaoState Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-Biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China.

Chenran ZhenState Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-Biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China.

Yanshuai CuiHebei Key Laboratory of Agroecological Safety, Department of Environmental Engineering, Hebei University of Environmental Engineering, Qinhuangdao 066102, China.

Xianbing JiHebei Key Laboratory of Agroecological Safety, Department of Environmental Engineering, Hebei University of Environmental Engineering, Qinhuangdao 066102, China.

Ruyu LiState Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-Biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China.

Longgang WangState Key Laboratory of Metastable Materials Science and Technology, Hebei Key Laboratory of Nano-Biotechnology, Hebei Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China.

Funding

Hebei Natural Science Foundation H2022203004Hebei University of Environmental Engineering XJXM-ZD-2024001

6 · The paper itself

Abstract

The content of glutathione in the human body is crucial to human health, so a convenient and efficient method is needed to detect it. Herein, porous coordination network-224 (PCN-224) was modified by polydopamine to prepare polydopamine-modified PCN-224 (PCN-224-PDA) to improve the water dispersibility of the PCN-224. Monodispersed platinum nanoparticles were loaded into the PCN-224-PDA to prepare PCN-224-PDA-Pt. The PCN-224-PDA-Pt showed high peroxidase-like catalytic activity, and its catalytic activity was affected by pH and temperature. The PCN-224-PDA-Pt almost had no hemolysis of red blood cells. In addition, the PCN-224-PDA-Pt showed high affinity for 3,3',5,5'-tetramethylbenzidine and catalytic efficiency in kinetic studies, and the type of reactive oxygen species generated during the catalytic process was hydroxyl radicals. More importantly, a colorimetric method for glutathione detection was developed based on the peroxidase-like activity of the PCN-224-PDA-Pt. The linear detection range was 1-600 μM and the detection limit reached 0.306 μM. This method shows good anti-interference capabilities and excellent recovery rates, indicating its strong potential for applications in biological detection.

Indexed as

GlutathioneIndolesMetal NanoparticlesPlatinumPolymersBenzidinesCatalysisColorimetryHumansLimit of DetectionPeroxidasePorosityBenzidinesGlutathioneIndolesPeroxidasePlatinumpolydopaminePolymerscolorimetric detectionglutathionenanozymePCN-224

Identifiers

PMID40723874

DOI10.3390/biom15071002

PMCPMC12293988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.