Evidence map›Paper›PMID 40723843›Full record

ArticleBiomolecules2025

Predictive and Prognostic Relevance of ABC Transporters for Resistance to Anthracycline Derivatives.

Rümeysa Yücer, Rossana Piccinno, Ednah Ooko, Mona Dawood, Gerhard Bringmann, Thomas Efferth

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rümeysa YücerDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0000-0002-9678-3323
Rossana PiccinnoInstitute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany.
Ednah OokoLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8275-927X
Mona DawoodDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.
Gerhard BringmannInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0002-3583-5935
Thomas EfferthDepartment of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany.ORCID 0000-0002-2637-1681

Funding

NCI NIH HHS Postdoc GrantTheophrastus Paracelsus Foundation 64367
6 · The paper itself

Abstract

Anthracyclines have been clinically well established in cancer chemotherapy for decades. The main limitations of this drug class are the development of resistance and severe side effects. In the present investigation, we analyzed 30 anthracyclines in a panel of 59 cell lines of the National Cancer Institute, USA. The log

Indexed as

AnthracyclinesATP-Binding Cassette TransportersDrug Resistance, NeoplasmAntineoplastic AgentsCell Line, TumorFemaleHumansMolecular Docking SimulationPrognosisAnthracyclinesAntineoplastic AgentsATP-Binding Cassette Transportersanthracyclineschemotherapydrug developmentKaplan–Meier statisticsmolecular dockingmultidrug resistancethe cancer genome atlas (TCGA)

Identifiers

PMID40723843
PMCPMC12292137

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.