Evidence map›Paper›PMID 40723800›Full record

ArticleBiomolecules2025

Immune Signatures in Post-Acute Sequelae of COVID-19 (PASC) and Myalgia/Chronic Fatigue Syndrome (ME/CFS): Insights from the Fecal Microbiome and Serum Cytokine Profiles.

Martin Tobi, Diptaraj Chaudhari, Elizabeth P Ryan, Noreen F Rossi, Orena Koka, Bridget Baxter, Madison Tipton, Taru S Dutt, Yosef Tobi, Benita McVicker and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. VSL#3British journal of biomedical science · 2026
    Trial
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Martin TobiR&D Department, John D. Dingell VAMC, 4646 John R Street, Detroit, MI 48201, USA.
Diptaraj ChaudhariDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48301, USA.ORCID 0000-0001-9236-7683
Elizabeth P RyanDepartment of Environmental and Radiological Health Sciences, School of Health System, Public Health, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-1577-0919
Noreen F RossiR&D Department, John D. Dingell VAMC, 4646 John R Street, Detroit, MI 48201, USA.ORCID 0000-0002-5886-427X
Orena KokaDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48301, USA.
Bridget BaxterDepartment of Environmental and Radiological Health Sciences, School of Health System, Public Health, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Madison TiptonDepartment of Environmental and Radiological Health Sciences, School of Health System, Public Health, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Taru S DuttDepartment of Environmental and Radiological Health Sciences, School of Health System, Public Health, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-5101-1311
Yosef TobiR&D Department, John D. Dingell VAMC, 4646 John R Street, Detroit, MI 48201, USA.ORCID 0000-0003-0781-7681
Benita McVickerDepartment of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68005, USA.ORCID 0000-0001-7876-149X
Mariana Angoa-PerezR&D Department, John D. Dingell VAMC, 4646 John R Street, Detroit, MI 48201, USA.ORCID 0000-0002-9749-1197

Funding

BLRD VA I01 BX004757BLRD VA I21 BX005850VA Merit Review Grant Awards (MT) and a Merit R&D #BX004127 (B.H.M. and M.T.).
6 · The paper itself

Abstract

While there are many postulates for the etiology of post-viral chronic fatigue and other symptomatology, little is known. We draw on our past experience of these syndromes to devise means which can expose the primary players of this malady in terms of a panoply participating biomolecules and the state of the stool microbiome. Using databases established from a large dataset of patients at risk of colorectal cancer who were followed longitudinally over 3 decades, and a smaller database dedicated to building a Long PASC cohort (Post-Acute Sequelae of COVID-19), we were able to ascertain factors that predisposed patients to (and resulted in) significant changes in various biomarkers, i.e., the stool microbiome and serum cytokine levels, which we verified by collecting stool and serum samples. There were significant changes in the stool microbiome with an inversion from the usual

Indexed as

COVID-19CytokinesFatigue Syndrome, ChronicFecesGastrointestinal MicrobiomeAdultBiomarkersFemaleHumansMaleMiddle AgedPost-Acute COVID-19 SyndromeSARS-CoV-2BiomarkersCytokinesAdnab-9animal modelschronic fatiguechronic fatigue syndromeCOVID-19cytokinescytomegalovirusdatabaseEpstein Barr Virusinnate immune systemLong COVIDmyalgic/encephalitisoligo-A-synthetasep87PASC (Post Acute Sequelae of SARS-CoV-2 infection) or post-acute sequelae of COVID-19post-viral symptomsstool microbiome

Identifiers

PMID40723800
PMCPMC12292560

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.