ArticleAnimals : an open access journal from MDPI2025
Evaluation of the Urine Albumin-to-Creatinine Ratio (UAC) for Early Renal Disease: A Large-Scale Clinical Study in Cats.
Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Chronic renal disease detection developments with future potential to improve veterinary clinical practice.Frontiers in veterinary science · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
CKD is a leading cause of illness in older cats, but early detection is challenging due to the limitations of conventional biomarkers. This study evaluated the clinical utility of the UAC for identifying early-stage renal dysfunction in cats and proposed a diagnostic matrix incorporating the UAC with other biomarkers. Blood and urine samples from 59 healthy cats and 190 cats with CKD were analyzed, and UAC levels were compared with symmetric dimethylarginine (SDMA), creatinine, and blood urea nitrogen (BUN). UAC values were significantly elevated in cats with CKD, including those in stage 1. Receiver operating characteristic analysis identified a UAC cut-off of 16.3 mg/g, yielding 100% specificity and 43.7% sensitivity for early-stage CKD classification. The UAC showed significant correlations with other renal biomarkers and was incorporated into a multi-parameter matrix to support disease staging. These findings suggest that the UAC may be a promising supplementary biomarker for evaluating renal function in cats and could aid clinical decision-making when interpreted in conjunction with established diagnostic parameters.
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