The Prognostic Role of Tertiary Lymphoid Structures and Immune Microenvironment Signatures in Early-Stage

Wei-Hsun Hsu, Chia-Chi Hsu, Min-Shu Hsieh, James Chih-Hsin Yang

Abstract read

In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The impact of local tumor immune responses on prognosis in resected lung adenocarcinoma.Translational lung cancer research · 2026
Article
Mechanistic roles and clinical applications of tertiary lymphoid structures in colorectal cancer drug resistance.Cancer drug resistance (Alhambra, Calif.) · 2026
Review

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wei-Hsun HsuGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0009-0009-1740-1832

Chia-Chi HsuGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0003-1532-7017

Min-Shu HsiehDepartment of Pathology, National Taiwan University Cancer Center, National Taiwan University Hospital, Taipei 106, Taiwan.ORCID 0000-0002-0594-3732

James Chih-Hsin YangGraduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-5586-5138

Funding

Ministry of Education, Taiwan NTU-110L901404Ministry of Science & Technology, Taiwan 110-2314-B-002-222-MY3Ministry of Science & Technology, Taiwan 111-2634-F-002-017Ministry of Science & Technology, Taiwan 111-2811-B-002-058Ministry of Science & Technology, Taiwan 113-2314-B-002-114

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe role of tertiary lymphoid structures (TLSs) in cancer prognosis is well established, yet their significance in early-stage

methodsTLSs were identified in tumor samples using multiplex immunohistochemistry (IHC), and their density was quantified. The PD-L1 tumor proportion score (TPS) and TLS density were analyzed for associations with disease-free survival (DFS). Gene expression profiling was performed to compare tumor microenvironment signatures between high- and low-TLS-density groups.

resultsHigh TLS density correlated with significantly longer DFS (43 vs. 20.5 months,

conclusionsIn summary, TLS density is a potential prognostic biomarker for DFS in early-stage

Indexed as

disease-free survivalEGFR-mutant lung adenocarcinomatertiary lymphoid structuretumor immune microenvironment

Identifiers

PMID40723259

DOI10.3390/cancers17142379

PMCPMC12293609

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