ArticleCancers2025
Breast Edema After Breast-Conserving Surgery and Radiotherapy: Introduction of a Clinically Meaningful Classification and Evaluation of the Incidence After Normo- and Hypofractionated Treatments.
Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Acute breast edema during 5-fraction ultra-hypofractionated radiotherapy after breast-conserving surgery: A cone-beam CT based evaluation.Clinical and translational radiation oncology · 2027Article
- Breast Edema in Women With Arm Lymphedema Following Breast-Conserving Surgery: A Systematic Review.Cureus · 2026Review
- Association between radiation volume and breast density for skin toxicity and breast edema after radiotherapy in breast conserving therapy of breast cancer.Radiation oncology (London, England) · 2026Article
- Inter-breast Ratios of Tissue Dielectric Constant Values to Detect and Track Unilateral Breast Edema or Lymphedema.Cureus · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
BE following RT after breast-conserving surgery is a common concern, impacting patients' quality of life. This study introduces a clinically meaningful classification system for BE and retrospectively evaluates its incidence among patients treated with normofractionated (nfRT) and hypofractionated (hfRT) regimens. Data from 1156 patients treated between 2011 and 2021 were analyzed. BE was graded according to the CTC and a so-called "WST classification" (grade 1: lymphatic drainage performed by the patient; grade 2: professional lymphatic drainage; grade 3: surgery). A total of 33%/17% developed BE according to the WST classification/CTC. Grade III BE was not reported. About 70% experienced a remission of BE during follow-up. Risk factors for the development of BE included RT of lymphatic drainage, complete axillary dissection compared to sentinel node dissection, and CTX. CTX was not confirmed in multivariate analysis. The incidence of BE did not differ significantly between the nfRT and hfRT groups, affirming the safety and comparability of hfRT regarding BE risk (HR: 0.833,
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