Evidence map›Paper›PMID 40723185›Full record

ReviewCancers2025

Challenges in the Diagnosis of Biliary Stricture and Cholangiocarcinoma and Perspectives on the Future Applications of Advanced Technologies.

Kevin Gaston, Abdelkhalick Mohammad, Suresh Vasan Venkatachalapathy, Ioan Notingher, George S D Gordon, Arvind Arora, Frankie J Rawson, Jane I Grove, Abhik Mukherjee, Dhanny Gomez and 2 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kevin GastonBiodiscovery Institute, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-7349-5513
Abdelkhalick MohammadMechanical, Material and Manufacturing Engineering, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.
Suresh Vasan VenkatachalapathyNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham NG7 2RD, UK.
Ioan NotingherSchool of Physics and Astronomy, University of Nottingham, Nottingham NG7 2RD, UK.
George S D GordonOptics and Photonics Research Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, UK.
Arvind AroraBiodiscovery Institute, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
Frankie J RawsonLaboratory of Bioelectronics, Regenerative Medicine & Cellular Therapies, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Jane I GroveNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham NG7 2RD, UK.
Abhik MukherjeeNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham NG7 2RD, UK.
Dhanny GomezNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham NG7 2RD, UK.
Padma-Sheela JayaramanBiodiscovery Institute, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.
Guruprasad P AithalNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0003-3924-4830

Funding

UK Research and Innovation APP25626
6 · The paper itself

Abstract

In the management of cholangiocarcinoma, effective biliary drainage and accurate diagnosis are vital to allow further treatment. Confirmation of tissue diagnosis and molecular characterization is also required to guide future treatment options including surgery and chemotherapy as well as the possible use of personalized treatments that target specific mutations present within individual tumours. Initial CT or MRI scans may be followed by endoscopic ultrasound (EUS) or endoscopic retrograde cholangiopancreatography (ERCP) to obtain tissue samples. However, these methods often fall short due to difficulty in accessing entire bile duct strictures. SpyGlass cholangioscopy can improve diagnosis, yet may fail to provide sufficient tissue for molecular characterization. Here we present a perspective on the development of snake-like agile robots with integrated optical imaging and Raman spectroscopy. These robots could improve the mapping of the biliary tree and the precision of biopsy collection and allow tissue analysis in situ, as well as facilitating stenting to restore the flow of bile. A multidisciplinary approach that brings together clinicians, pathologists, and engineers is required to develop these new robotic technologies and improve patient outcomes.

Indexed as

bile ductcholangiocarcinomacholestasisliver cancerrobotics

Identifiers

PMID40723185
PMCPMC12293532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.