ArticleChildren (Basel, Switzerland)2025
Non-Invasive Capnography Versus Pulse Oximetry for Early Detection of Respiratory Depression During Pediatric Procedural Sedation: A Prospective Observational Study.
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A comprehensive systematic review and meta-analysis of the safety of procedural sedation in pediatric emergency rooms.Italian journal of pediatrics · 2026Pooled it
- Seeing beyond the numbers: capnography as a vital tool in pediatric emergency care.International journal of emergency medicine · 2026Review
- End-tidal COFrontiers in physiology · 2026Article
- Methodological Caution in Interpreting Efficacy and Safety of Ciprofol-Alfentanil Sedation for Pediatric Bronchoscopy [Letter].Drug design, development and therapy · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesContinuous ventilation monitoring during pediatric sedation is essential, as respiratory depression may occur silently and may not be detected promptly by conventional methods such as pulse oximetry. Non-invasive capnography has been proposed to improve early detection of respiratory compromise. This prospective observational study evaluated the diagnostic accuracy of non-invasive capnography, compared to pulse oximetry, for detecting respiratory depression in pediatric patients undergoing sedation.
methodsWe conducted a single-center, prospective observational study at a tertiary pediatric hospital, enrolling 101 patients (ages 1-17 years) undergoing sedation for diagnostic or therapeutic procedures. Patients were monitored using both pulse oximetry and non-invasive capnography. Episodes of respiratory depression-defined as apnea, hypopneic hypoventilation, bradypneic hypoventilation, and desaturation-were recorded. We compared the diagnostic performance and time to detection between capnography and pulse oximetry.
resultsWe identified 93 episodes of respiratory depression in 52 patients (51.1%). Capnography detected all apnea episodes and 76.9% of hypopneic hypoventilation episodes that were not identified by pulse oximetry. The median time advantage of capnography over pulse oximetry was 35 s (
conclusionsNon-invasive capnography improves the early detection of respiratory depression compared to conventional monitoring with pulse oximetry in pediatric procedural sedation. While these findings support its routine use to enhance patient safety, larger multicenter studies are needed to demonstrate its diagnostic accuracy and impact on clinical outcomes.
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