ReviewAntioxidants (Basel, Switzerland)2025
Betaine Dietary Supplementation: Healthy Aspects in Human and Animal Nutrition.
Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Exerkines in precision management of metabolic diseases.Chinese medical journal · 2026Review
- Betaine in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms of Action and Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2026Review
- A Review on Heat Stress in Broiler Chickens: Mechanisms, Effects and Mitigation Strategies.Veterinary medicine and science · 2026Review
- Extraction and Thermal Stability of Chlorogenic Acid from Green Coffee and Yerba Mate in Food-Based Solvents.ACS omega · 2026Article
- Article
- Muscle Quality Responses of Pearl Gentian Grouper (Foods (Basel, Switzerland) · 2026Article
- Effects of Dietary Betaine on Growth Performance, Serum Metabolites, and Meat Quality of Pigs: A Meta-Analysis.Animals : an open access journal from MDPI · 2026Review
- Article
- Tissue-Specific Transcriptomic Profiling of Vitamin-Dependent Mitochondrial Pathways in Female Buffalo.Cell biochemistry and biophysics · 2026Article
- Dietary dimethylglycine sodium salt improves growth performance, liver function, and meat quality of broilers exposed to heat stress.Poultry science · 2026Article
- Natural liquid betaine dietary supplementation improves growth performance, immuno-antioxidant responses, and stress resistance in Nile tilapia subjected to acute ammonia challenge.Scientific reports · 2026Article
- Integrated Analysis of Transcriptome and Metabolome Reveals Molecular Responses to Ammonia Stress in the Gills ofBiology · 2026Article
- Canine Cognitive Dysfunction and Alzheimer's Disease: Pathophysiological Relationships and the Impact of Glymphatic System Impairment on Neurodegeneration.Veterinary sciences · 2026Review
- Short-Term Impact of Betaine Supplementation on Ruminal Microbial Relative Abundance, Nutrient Digestibility, Serum Metabolites, and Milk Composition in Heat-Stressed Dairy Cows.Veterinary medicine and science · 2026Article
- Betaine Inhibits Ferroptosis After Intracerebral Hemorrhage by Activating the Nrf2/HO-1 Pathway.Antioxidants (Basel, Switzerland) · 2026Article
- Interactions between betaine, insulin resistance, and cognitive impairment in people with and without HIV.Frontiers in immunology · 2026Article
- Taurine and betaine promote lactate clearance in canine hepatocytes by enhancing gluconeogenesis.Frontiers in veterinary science · 2026Article
- Heat Stress and Betaine Affect Lipolysis in Pig Adipose Tissue Explants.Animals : an open access journal from MDPI · 2025Article
- The multi-protective role of dietary betaine in largemouth bass (Frontiers in physiology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Betaine, a naturally occurring compound primarily derived from sugar beet by-products, has attracted increasing attention for its multifaceted roles in human and animal nutrition. Acting as both an osmolyte and a methyl group donor, betaine contributes to cellular hydration, methylation balance, antioxidant defense, and metabolic regulation. This review provides a comprehensive overview of betaine's biological functions and its health-promoting effects across species. In humans, betaine supports hepatic function, cardiovascular health, renal protection, and physical performance, mainly by modulating homocysteine metabolism, lipid profiles, and oxidative stress. In animal production systems, it enhances growth, feed efficiency, reproductive performance, and resilience to heat stress, with species-specific applications in monogastrics, ruminants, aquaculture species, and companion animals. The review also explores the molecular mechanisms underlying betaine's effects, including epigenetic regulation and mitochondrial function, and presents updated evidence on its biosynthesis, bioavailability, and nutrient interactions. Furthermore, the use of betaine derived from agro-industrial by-products aligns with the principles of the circular economy, promoting the sustainable reuse of valuable compounds within the agri-food chain. Despite promising findings, further research is needed to standardize effective dosages and clarify species-specific responses under different physiological and environmental conditions. Overall, betaine emerges as a promising and sustainable functional ingredient with wide-ranging applications in nutrition and health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.