Evidence map›Paper›PMID 40722561›Full record

ReviewDiagnostics (Basel, Switzerland)2025

Efficacy and Safety of Intravenous Thrombolysis Beyond 4.5 Hours in Ischemic Stroke: A Systematic Review and Meta-Analysis.

Muhammad Ahmad, Chavin Akalanka Ranasinghe, Mais Omar Abu-Sa'da, Durga Prasad Bhimineni, Muhammed Ameen Noushad, Talal Warsi, Ahmad Mesmar, Munikaverappa Anjanappa Mukesh, Sagar K Patel, Gabriel Imbianozor and 6 more

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Muhammad AhmadJunior Clinical Fellow Geriatrics/Acute Medicine, Aneurin Bevan University Healthboard, Caerleon NP18 3XQ, UK.
Chavin Akalanka RanasingheDepartment of Cardiology, Queen Elizabeth Hospital Birmingham, Birmingham B15 2GW, UK.
Mais Omar Abu-Sa'daRAKCOMs, RAK Medical Health Sciences University, Ras Al Khaimah 11172, United Arab Emirates.
Durga Prasad BhimineniCardiology, West Suffolk NHS Foundation Trust, Bury St Edmunds, Suffolk IP33 2QZ, UK.ORCID 0000-0001-9045-525X
Muhammed Ameen NoushadNeurology, University Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, UK.
Talal WarsiCardiology, University Hospitals Plymouth NHS Trust, Plymouth PL6 8DH, UK.ORCID 0009-0001-7545-1856
Ahmad MesmarCardiology Department, Sheikh Shakhbout Medical City, Abu Dhabi P.O. Box 11001, United Arab Emirates.ORCID 0000-0001-9986-8034
Munikaverappa Anjanappa MukeshInternal Medicine, South Tyneside and Sunderland NHS Foundation Trust, Sunderland R4 7TP, UK.
Sagar K PatelGujarat Adani Institute of Medical Sciences, Bhuj 370001, Gujarat, India.ORCID 0009-0002-0093-9504
Gabriel ImbianozorRoyal Wolverhampton NHS Trust, Wolverhampton WV10 0QP, UK.
Ali Mustansir BhattyHull University Teaching Hospital NHS Trust, Hull HU1 3SA, UK.
Ahmad AlareedUniversity Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
Quratul AinDepartment of Medicine, Rotherham General Hospital, Rotherham S60 2UD, UK.
Eeshal ZulfiqarDepartment of Medicine, Dow University of Health Sciences, Karachi 75280, Pakistan.ORCID 0009-0009-6346-6629
Mushood AhmedDepartment of Medicine, Rawalpindi Medical University, Rawalpindi 46000, Pakistan.ORCID 0000-0001-9872-8224
Raheel AhmedNational Heart & Lung Institute, Imperial College London, London W12 0NN, UK.ORCID 0000-0003-2814-7314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alteplaseischemic strokemeta-analysistenecteplasethrombolysis

Identifiers

PMID40722561
PMCPMC12293326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.