Evidence map›Paper›PMID 40722493›Full record

ReviewDiagnostics (Basel, Switzerland)2025

How to Perform Cardiac Contrast-Enhanced Ultrasound (cCEUS): Part I.

Harald Becher, Andreas Helfen, Guido Michels, Nicola Gaibazzi, Roxy Senior, Christoph Frank Dietrich

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Harald BecherMazankowski Alberta Heart Institute, Edmonton, AB T6G 2B7, Canada.ORCID 0000-0001-8770-8594
Andreas HelfenSt. Marien Hospital, 44534 Lünen, Germany.ORCID 0000-0002-3921-3594
Guido MichelsNotfallzentrum, Krankenhaus der Barmherzigen Brüder Trier, 54292 Trier, Germany.ORCID 0000-0002-5063-5157
Nicola GaibazziDepartment of Cardiology, University of Parma, 43124 Parma, Italy.ORCID 0000-0002-2207-3388
Roxy SeniorRoyal Brompton Hospital, National Heart and Lung Institute, Imperial College, London SW3 6NP, UK.ORCID 0000-0001-6579-7039
Christoph Frank DietrichDepartment General Internal Medicine (DAIM), Hospitals Hirslanden Bern Beau Site, Salem and Permanence, 3013 Bern, Switzerland.ORCID 0000-0001-6015-6347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound enhancing agents (UEAs, formerly called contrast agents) for assessments of the left heart have improved the applicability of echocardiography and the accuracy of echocardiographic measurements. UEAs have been recommended for several diagnostic echocardiographic procedures by national and supernational agencies. The increased use of UEAs during the last years provided more evidence and experience in clinical practice data which is helpful for optimizing the UEA procedures and which will be useful for both newcomers to UEA in echocardiography and sonographers/physicians with experience in echocardiography with UEAs. In two parts, this review focuses on the "how to do" for the approved UEA applications. This is part 1, covering the available UEAs and providing specific guidance on the assessment of global and regional LV function. Part 2 covers the imaging of myocardial disease and masses as well as myocardial perfusion. Recommendations include the application of UEAs in two-dimensional echocardiography as there is limited data on three-dimensional echocardiography. A step-by-step approach is proposed for each of the procedures as well as guidance on how to interpret recordings and how to report them.

Indexed as

cardiomyopathycontrast agentcontrast-enhanced ultrasoundechocardiographyLV functionthrombustumorultrasound enhancing agent

Identifiers

PMID40722493
PMCPMC12294039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.