Modeling and Dynamic Parameterized Predictive Control of Dissolved Oxygen in Dual-Tank Bioreactor Systems.

Muhang Li, Ran Tang, Yifei Li, Junning Cui

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Muhang LiCenter of Ultra-Precision Optoelectronic Instrument Engineering, Harbin Institute of Technology, Harbin 150080, China.ORCID 0000-0003-2374-0039

Ran TangCenter of Ultra-Precision Optoelectronic Instrument Engineering, Harbin Institute of Technology, Harbin 150080, China.

Yifei LiSchool of Mathematics, Harbin Institute of Technology, Harbin 150001, China.

Junning CuiCenter of Ultra-Precision Optoelectronic Instrument Engineering, Harbin Institute of Technology, Harbin 150080, China.ORCID 0000-0002-4418-8936

Funding

National Natural Science Foundation of China No. 52375532Natural Science Foundation of Heilongjiang Province of China No. LH2023C071

6 · The paper itself

Abstract

Uneven distribution and delayed system response of dissolved oxygen (DO) in dual-tank recirculating bioreactor systems pose significant challenges for oxygen supply. To address these issues, a dynamic parameterized predictive control (DPPC) approach is proposed and validated through simulation and bench-scale experiments. This method is underpinned by a mathematical model that integrates mass transfer kinetics and chemical thermodynamic principles, accurately capturing oxygen dissolution and transfer within a recirculating environment. By predicting future DO variations and continuously integrating real-time monitoring data, the controller adjusts oxygen injection parameters in real time, rapidly restoring DO levels to target values while minimizing overshoot and latency introduced by system circulation. Experimental results in dual-tank setups show an RMSE below 0.05 and an R

Indexed as

bioreactor optimizationdissolved oxygendynamic parameterized predictive controloxygen distributionrecirculating culture

Identifiers

PMID40722382

DOI10.3390/bioengineering12070690

PMCPMC12292632

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.