Evidence map›Paper›PMID 40722380›Full record

ArticleBioengineering (Basel, Switzerland)2025

Different Expression of Vascularization and Inflammatory Regulators in Cells Derived from Oral Mucosa and Limbus.

Eleni Voukali, Joao Victor Cabral, Natalia Smorodinova, Vojtech Kolin, Magdalena Netukova, Tomáš Vacík, Katerina Jirsova

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eleni VoukaliInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.ORCID 0000-0001-6029-6171
Joao Victor CabralInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.ORCID 0000-0003-4898-5163
Natalia SmorodinovaInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.
Vojtech KolinDepartment of Pathology of the Third Medical Faculty, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic.
Magdalena NetukovaOphthalmology Department of the Third Medical Faculty, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic.
Tomáš VacíkInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.ORCID 0000-0003-0797-7757
Katerina JirsovaInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague, Czech Republic.ORCID 0000-0002-4625-6701

Funding

Charles University Cooperation: Medical Diagnostics and Basic Medical SciencesNorway Grants and Technology Agency of the Czech Republic KAPPA Project No. TO01000099
6 · The paper itself

Abstract

Bilateral limbal stem cell deficiency (LSCD) can be effectively treated with cultivated oral mucosa epithelial cell transplantation (COMET). However, COMET is associated with greater superficial neovascularization than limbal stem cell (LESC) transplantation, the gold standard for unilateral LSCD. To investigate the intrinsic molecular features of cells intended for grafting, we assessed the in vitro expression of genes involved in vascularization and inflammation using real-time quantitative PCR and multifactorial linear models. Oral mucosal epithelial cells (OMECs) and limbal epithelial cells (LECs) were cultured in either conventional (COM) or xenobiotic-free (XF) media on fibrin substrates. Gene expression profiling revealed distinct transcriptional signatures. The pro-angiogenic genes

Indexed as

angiogenesis-related genesgene expressioninflammation regulatory geneslimbal epithelial cellsLimbal stem cell deficiencyoral mucosal epithelial cells

Identifiers

PMID40722380
PMCPMC12292335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.