ReviewBrain sciences2025
Post-Concussion Syndrome and Functional Neurological Disorder: Diagnostic Interfaces, Risk Mechanisms, and the Functional Overlay Model.
Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Functional Neurological Symptoms After Mild Traumatic Brain Injury: A Scoping Review and Framework for Differentiating Functional and Organic Post-Concussion Presentations.Life (Basel, Switzerland) · 2026Review
- Cognitive rehabilitation for functional neurological disorder.CNS spectrums · 2025Review
- Functional Cognitive Disorder: diagnostic challenges, clinical features, and future directions in a misunderstood condition.Frontiers in aging neuroscience · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-concussion syndrome (PCS) and Functional Neurological Disorder (FND), including Functional Cognitive Disorder (FCD), are two frequently encountered but diagnostically complex conditions. While PCS is conceptualized as a sequela of mild traumatic brain injury (mTBI), FND/FCD encompasses symptoms incompatible with recognized neurological disease, often arising in the absence of structural brain damage. Yet, both conditions exhibit considerable clinical overlap-particularly in the domains of cognitive dysfunction, emotional dysregulation, and symptom persistence despite negative investigations.
objectiveThis review critically examines the shared and divergent features of PCS and FND/FCD. We explore their respective epidemiology, diagnostic criteria, and risk factors-including personality traits and trauma exposure-as well as emerging insights from neuroimaging and biomarkers. We propose the "Functional Overlay Model" as a clinical tool for navigating diagnostic ambiguity in patients with persistent post-injury symptoms.
resultsPCS and FND/FCD frequently share features such as subjective cognitive complaints, fatigue, anxiety, and heightened somatic vigilance. High neuroticism, maladaptive coping, prior psychiatric history, and trauma exposure emerge as common risk factors. Neuroimaging studies show persistent network dysfunction in both PCS and FND, with overlapping disruption in fronto-limbic and default mode systems. The Functional Overlay Model helps to identify cases where functional symptomatology coexists with or replaces an initial organic insult-particularly in patients with incongruent symptoms and normal objective testing.
conclusionsPCS and FND/FCD should be conceptualized along a continuum of brain dysfunction, shaped by injury, psychology, and contextual factors. Early recognition of functional overlays and stratified psychological interventions may improve outcomes for patients with persistent, medically unexplained symptoms after head trauma. This review introduces the Functional Overlay Model as a novel framework to enhance diagnostic clarity and therapeutic planning in patients presenting with persistent post-injury symptoms.
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