Evidence map›Paper›PMID 40722316›Full record

ReviewBrain sciences2025

The Challenge of Diagnosing Labyrinthine Stroke-A Critical Review.

Alexander A Tarnutzer, Sun-Uk Lee, Ji-Soo Kim, Diego Kaski

Abstract readReview
In one paragraph

Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Temporal enhancement patterns on 3D-FLAIR MRI in labyrinthine infarction.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  2. Case report and literature review of subclavian steal syndrome presenting with otologic symptoms as the initial clinical manifestation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Review
  3. Acute vertigo: stroke or not?Current opinion in neurology · 2026
    Review
  4. Association of Systemic Hemodynamics and Endothelial Dysfunction With Clinical Phenotypes in Sensorineural Hearing Loss With Vertigo: A Cross-Sectional Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander A TarnutzerNeurology, Cantonal Hospital of Baden, 5404 Baden, Switzerland.ORCID 0000-0002-6984-6958
Sun-Uk LeeNeurotology and Neuro-Ophthalmology Laboratory, Korea University Medical Center, Seoul 02841, Republic of Korea.ORCID 0000-0001-8660-7759
Ji-Soo KimDizziness Center, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam 13620, Republic of Korea.ORCID 0000-0002-1508-2024
Diego KaskiSENSE Research Unit, Department of Clinical and Movement Neurosciences, Institute of Neurology, University College London, 33 Queen Square, London WC1N 3BG, UK.ORCID 0000-0002-0591-646X

Funding

National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre N/ANational Research Foundation of Korea NRF-2021R1F1A1061527National Research Foundation of Korea RS-2025-00515755University Anam Hospital, Seoul, Republic of Korea O2514421
6 · The paper itself

Abstract

Acute vertigo or dizziness that is accompanied by a sudden sensorineural hearing loss (SSNHL) often poses a diagnostic challenge. While a combined audiovestibular deficit makes an inner ear pathology most likely, this does not necessarily exclude a vascular pathology that may be a harbinger of future sinister events. This is especially true for strokes within the territory of the anterior inferior cerebellar artery (AICA), because the labyrinth receives its vascular supply most often by branches of the AICA. Thus, acute labyrinthine ischemia may present in combination with focal neurologic deficits, but also in isolation or as a warning sign before focal stroke signs arise. How can labyrinthine ischemia be differentiated from an idiopathic SSNHL? In this critical review, we discuss both the pathophysiology and the differential diagnosis of acute audiovestibular deficits. We will also address the value of state-of-the-art MR imaging in visualizing labyrinthine ischemia. Finally, we will discuss treatment options and review the prognosis of acute audiovestibular deficits.

Indexed as

acute vestibular syndromehearing lossimaginginner earstrokevertigo

Identifiers

PMID40722316
PMCPMC12293903

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.