Evidence map›Paper›PMID 40722311›Full record

ReviewBrain sciences2025

Biofeedback for Motor and Cognitive Rehabilitation in Parkinson's Disease: A Comprehensive Review of Non-Invasive Interventions.

Pierluigi Diotaiuti, Giulio Marotta, Salvatore Vitiello, Francesco Di Siena, Marco Palombo, Elisa Langiano, Maria Ferrara, Stefania Mancone

Abstract readReview
In one paragraph

Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pierluigi DiotaiutiDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.ORCID 0000-0002-5470-3233
Giulio MarottaDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.ORCID 0009-0004-4624-9239
Salvatore VitielloDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.
Francesco Di SienaDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.
Marco PalomboDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.
Elisa LangianoDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.
Maria FerraraDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.ORCID 0000-0003-0781-427X
Stefania ManconeDepartment of Human Sciences, Society and Health, University of Cassino and Southern Lazio, 03043 Cassino, Italy.ORCID 0000-0002-9837-526X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Biofeedback and neurofeedback are gaining attention as non-invasive rehabilitation strategies in Parkinson's disease (PD) treatment, aiming to modulate motor and non-motor symptoms through the self-regulation of physiological signals. (2) Objective: This review explores the application of biofeedback techniques, electromyographic (EMG) biofeedback, heart rate variability (HRV) biofeedback, and electroencephalographic (EEG) neurofeedback in PD rehabilitation, analyzing their impacts on motor control, autonomic function, and cognitive performance. (3) Methods: This review critically examined 15 studies investigating the efficacy of electromyographic (EMG), heart rate variability (HRV), and electroencephalographic (EEG) feedback interventions in PD. Studies were selected through a systematic search of peer-reviewed literature and analyzed in terms of design, sample characteristics, feedback modality, outcomes, and clinical feasibility. (4) Results: EMG biofeedback demonstrated improvements in muscle activation, gait, postural stability, and dysphagia management. HRV biofeedback showed positive effects on autonomic regulation, emotional control, and cardiovascular stability. EEG neurofeedback targeted abnormal cortical oscillations, such as beta-band overactivity and reduced frontal theta, and was associated with improvements in motor initiation, executive functioning, and cognitive flexibility. However, the reviewed studies were heterogeneous in design and outcome measures, limiting generalizability. Subgroup trends suggested modality-specific benefits across motor, autonomic, and cognitive domains. (5) Conclusions: While EMG and HRV systems are more accessible for clinical or home-based use, EEG neurofeedback remains technically demanding. Standardization of protocols and further randomized controlled trials are needed. Future directions include AI-driven personalization, wearable technologies, and multimodal integration to enhance accessibility and long-term adherence. Biofeedback presents a promising adjunct to conventional PD therapies, supporting personalized, patient-centered rehabilitation models.

Indexed as

autonomic regulationbiofeedbackcognitive Enhancementelectromyographyheart rate variabilitymotor rehabilitationneurofeedbacknon-pharmacological therapyParkinson’s diseasewearable neurotechnology

Identifiers

PMID40722311
PMCPMC12293922

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.