ReviewAdvanced materials (Deerfield Beach, Fla.)2025
Nanostructured Protein Surfaces Inspired by Spider Silk.
Review in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Bio-inspired programmable assembly of shape-memory and blood-reinforced cryogel for hemostasis and functional liver regeneration.Materials today. Bio · 2026Article
- Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non-Canonical Amino Acids.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Wrinkling-Based Patterning and Recombinant Spider Silk-Based Coating Technologies - Toward Novel Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Nanostructured Protein Surfaces Inspired by Spider Silk.Advanced materials (Deerfield Beach, Fla.) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spider silk is renowned for its exceptional mechanical properties, surpassing those of many natural and synthetic materials. This review focuses on biotechnologically produced recombinant spidroin variants inspired by well-understood major ampullate spider silk proteins (=spidroins), which are role models for understanding molecular composition, architecture, and the nanoscopic and mesoscopic structures formed through self-assembly and phase separation of spider silk fibers. The use of recombinant spidroins is explored to fabricate functionalized nanostructured surfaces, and molecular engineering is highlighted to tailor the interfacial properties of various morphologies, including particles, capsules, electrospun nanofibers, films/coatings, macroscopic nanofibril-based hydrogels, and nanohydrogel coatings. One focus is on functionalization of spidroins with peptide tags enabling a variety of affinity-based targets from cellular markers to inorganic nanoparticles, and allowing for instance specific drug delivery, cell accommodation in hydrogels, or bioselective immobilization of cells on surfaces. Furthermore, applying nanostructured spidroin coatings in combination with photo- and soft-lithography techniques is demonstrated, which can be used to produce micro- and nanostructured patterns exhibiting confined, spidroin-defined targeting, affinity, or repulsion properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.