Evidence map›Paper›PMID 40722033›Full record

ArticleStem cell research & therapy2025

Loss of G-protein coupled receptor 68 in hematopoietic tissues enhances long-term hematopoietic stem cell function upon aging.

Xiaofei He, Caleb Hawkins, Lauren Lawley, Tra Mi Phan, Isaac Park, Nicole Joven, Shanshan Shi, Jing Fang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaofei HeFirst Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
Caleb HawkinsDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA.
Lauren LawleyDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA.
Tra Mi PhanDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA.
Isaac ParkDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA.
Nicole JovenDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA.
Shanshan ShiDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA.
Jing FangDepartment of Drug Discovery and Biomedical Sciences, University of South Carolina College of Pharmacy, Columbia, SC, 29208, USA. fang8@cop.sc.edu.ORCID http://orcid.org/0000-0002-4950-626X

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
TISSUE BIOREPOSITORY COREP30GM103336 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI BERGER, FRANKLIN G. · 2013 to 2017
$5.4M
Targeting the p62 signalosome in leukemia.R01CA218076 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FANG, JING · 2017 to 2021
$1.7M
Aplastic Anemia and Myelodysplasia Association of Canada NSNational Institute for Health Care Management Foundation R01CA218076NCI NIH HHS R01 CA218076NIGMS NIH HHS P20 GM109091NIGMS NIH HHS P30 GM103336NIH COBRE 1P20GM109091-01
6 · The paper itself

Abstract

backgroundG-protein coupled receptor 68 (Gpr68) was enriched in long-term hematopoietic stem cells, indicating a potential role of Gpr68 in the HSC function. However, there is no significant phenotype in the HSC biology of Gpr68 whole-body KO mice, which may be counteracted by compensation. To study an intrinsic function of Gpr68 in hematopoiesis, Gpr68

methodsWe used complete blood counting and flow cytometry to determine the number and frequency of mature cells in normal hematopoiesis. We evaluated the number and function of stem cells after competitive bone marrow transplantation using cell surface immune markers. Biological functional experiments were used to explore the related cellular mechanisms.

resultsApart from a slightly increased megakaryocyte erythroid progenitor subpopulation, the number of hematopoietic stem and progenitor cells was unaltered in young and mid-aged Gpr68

conclusionLoss of Gpr68 in hematopoietic tissues enhances LT-HSC function upon aging by inhibiting a cell apoptosis.

Indexed as

AgingHematopoietic Stem CellsReceptors, G-Protein-CoupledAnimalsBone Marrow TransplantationHematopoiesisMiceMice, Inbred C57BLMice, KnockoutReceptors, G-Protein-CoupledAgingCalcium pathwayErythrocyte parametersGpr68Long-term hematopoietic stem cell

Identifiers

PMID40722033
PMCPMC12306079

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.