Evidence map›Paper›PMID 40722030›Full record

ArticleJournal of cardiothoracic surgery2025

NSUN2 inhibits NCOA4 expression to alleviate ferroptosis and inflammation in sepsis-induced myocardial injury in a m

BaYinchahan BoRanyi, Xinwei Lv, Dong Xiao

Abstract read
In one paragraph

Article in Journal of cardiothoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

BaYinchahan BoRanyiDepartment of Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, NO.91 Tianchi Road, Tianshan District, Urumqi, 830001, China.
Xinwei LvDepartment of Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, NO.91 Tianchi Road, Tianshan District, Urumqi, 830001, China.
Dong XiaoDepartment of Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Uygur Autonomous Region, NO.91 Tianchi Road, Tianshan District, Urumqi, 830001, China. icuzz@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis-induced myocardial injury (SIMI) leads to high morbidity and mortality. The 5-methylcytosine (m

methodsBoth an in vivo cecum ligation and puncture (CLP) SIMI rat model and an in vitro lipopolysaccharide (LPS)-treated H9c2 cardiomyocytes model were established. Reverse transcription (RT)-quantitative polymerase chain reaction (qPCR) was used to detect m

resultsNSUN2 alleviated LPS-induced SIMI by increasing cell viability and inhibiting inflammation and ferroptosis. In addition, NSUN2 inhibited NCOA4 expression in a m

conclusionsNSUN2 inhibited NCOA4 expression to alleviate ferroptosis and inflammation in SIMI in a m

Indexed as

FerroptosisInflammationMethyltransferasesNuclear Receptor CoactivatorsSepsisAnimalsDisease Models, AnimalMaleMyocytes, CardiacRatsRats, Sprague-DawleyMethyltransferasesNuclear Receptor CoactivatorsFerroptosisInflammationm5CNCOA4NSUN2Sepsis-induced myocardial injury

Identifiers

PMID40722030
PMCPMC12302838

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.