Evidence map›Paper›PMID 40722018›Full record

ArticleBMC ophthalmology2025

Changes in choriocapillaris blood flow density and associated factors affecting axial elongation in Chinese children and adolescents with mild to moderate myopia: a cross-sectional study.

Xin Cui, Liping Chen, Hui Zheng, Xin Meng, Lu Tian, Bin Wu, Shiyong Xie, Wei Wang, Xuefeng Shi

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Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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3 · Its place in the literature

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2 citing papers in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Xin Cui *Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Liping Chen *Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Hui ZhengTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, China.
Xin MengClinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Lu TianTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, China.
Bin WuTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, China.
Shiyong XieTianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, China.
Wei WangClinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
Xuefeng ShiClinical College of Ophthalmology, Tianjin Medical University, Tianjin, China. shixf_tmu@163.com.

Funding

the Project of Tianjin 131 Innovative Talent Team 201936the Science and Technology Fund for Health of Tianjin TJWJ2023ZD008the Science and Technology Planning Project of Tianjin 21JCYBJC00780Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK‑016A
6 · The paper itself

Abstract

backgroundTo investigate changes in choriocapillaris blood flow density (CFD) and identify factors influencing axial elongation in Chinese children and adolescents with mild to moderate myopia.

methodsA hospital-based cross-sectional study was conducted. A total of 288 participants aged 8 to 15 years were recruited from Tianjin Eye Hospital, including 186 children and adolescents with myopia and 102 age-matched participants without refractive error who served as the control group. Based on cycloplegic spherical equivalent (SE), the myopic participants were further categorized into moderate and mild myopia groups. Refractive power was determined through refraction tests, while various parameters-including axial length (AL) and choriocapillaris flow density (CFD)-were obtained through ophthalmic examinations. Statistical analyses were performed to examine changes in CFD and to identify factors associated with axial length.

resultsAL and SE differed significantly among all three groups (all P < 0.001). SFCT was significantly lower in the moderate myopia group compared to the mild myopia and control groups (P < 0.05 for both comparisons), while no significant differences in SFCT or FRT were found between the mild myopia and control groups(all P > 0.05).CFD-peri was significantly lower in the moderate myopia group compared to both the mild myopia and control groups (P = 0.006 and P < 0.001, respectively), while no significant differences were found in CFD-fovea or CFD-para among the three groups(P > 0.05).Spearman correlation analysis revealed significant negative correlations between AL and SE (r = -0.770), SFCT (r = -0.170), CFD-fovea (r = -0.347), CFD-para (r = -0.368), and CFD-peri (r = -0.359) (all P < 0.01). Hierarchical regression analysis identified SE (β = -0.751, P < 0.001) and CFD-peri (β = -0.118, P = 0.005) as independent predictors of axial length, with the final model explaining 71.5% of its variance (R² = 0.715).

conclusionChoriocapillaris blood flow density in the macular region changes in the early stages of myopia, showing decreases in the perifoveal region. Both SE and CFD-peri may serve as potential biomarkers for predicting axial length elongation in the early stage of myopia.

Indexed as

Axial Length, EyeChoroidMyopiaRegional Blood FlowAdolescentChildChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansMaleRefraction, OcularChoriocapillaris blood flow densityMild to moderate myopiaMyopia in Chinese children and adolescentsOptical coherence tomography angiography (OCTA)

Identifiers

PMID40722018
PMCPMC12302839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.