Evidence map›Paper›PMID 40722010›Full record

ArticleBMC complementary medicine and therapies2025

Acute and subacute toxicity of the aqueous extract of Cissus Polyantha Glig and Bradt (Vitaceae) on biochemical and hematological parameters in Wistar rats.

David Miaffo, Oulianovie Guessom Kamgue, Kilenma Kolefer, Elizé Dadaya, Talba Abba Mahamad, Barthelemy Maidadi, Albert Kamanyi

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Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Phytochemical Profile and Bioactive Potential ofAntioxidants (Basel, Switzerland) · 2026
    Article
  2. Acute and Subacute Oral Toxicity Evaluation ofFood science & nutrition · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David MiaffoDepartment of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroun. david_miaffo@yahoo.fr.
Oulianovie Guessom KamgueDepartment of Animal Science, Faculty of Agriculture and Veterinary Medicine, University of Buea, P.O. Box 63, Buea, Cameroon.
Kilenma KoleferDepartment of Environmental Sciences, Higher Institute of Agriculture, Wood, Water and Environment, University of Bertoua, P.O. Box 60, Belabo, Cameroon.
Elizé DadayaDepartment of Life Sciences, Faculty of Sciences, University of Bertoua, P.O. Box 652, Bertoua, Cameroon.
Talba Abba MahamadDepartment of Biological Sciences, Faculty of Sciences, University of Maroua, P.O. Box 814, Maroua, Cameroon.
Barthelemy MaidadiDepartment of Biological Sciences, Faculty of Sciences, University of Maroua, P.O. Box 814, Maroua, Cameroon.
Albert KamanyiDepartment of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCissus polyantha (C. polyantha) Glig and Bradt is a climbing plant of the Vitaceae family generally distributed in tropical regions and used in traditional African pharmacopoeia for the treatment of conjunctivitis, pain, inflammation, microbial diseases and diabetes mellitus. The aim of this study was to evaluate the acute and subacute toxicity of the aqueous extract from leafy stems of C. polyantha (AECP) in rats.

methodsIn acute toxicity, AECP was administered orally at a single dose of 2000 mg/kg. Clinical signs, general behavior and mortality were assessed for 14 days. In subacute toxicity, AECP at 111, 222 and 444 mg/kg was administered orally for 28 days. Body weight, internal organ weight, water intake, food consumption, biochemical parameters, hematological profile and histological examinations were evaluated.

resultsAcute toxicity results showed no signs of poisoning and no mortality. The mean lethal dose (LD

conclusionsIn acute toxicity, the LD

Indexed as

Plant ExtractsAnimalsFemaleLiverMaleRatsRats, WistarToxicity Tests, AcuteToxicity Tests, SubacutePlant ExtractsAcute toxicityAqueous extractBiochemical parametersCissus PolyanthaHaematological profileHistologySubacute toxicityWistar rats

Identifiers

PMID40722010
PMCPMC12302864

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.