ArticleWorld journal of surgery2025
Trends and Disparities in Appendicitis-Related Mortality Across U.S. Demographics and Regions: A 22-Year CDC WONDER Database Study.
Article in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Trends and Disparities in Appendicitis-Related Mortality Across U.S. Demographics and Regions: A 22-Year CDC WONDER Database Study.World journal of surgery · 2025Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAppendicitis remains a common surgical emergency with potentially fatal complications. Long-term trends in mortality disparities are not well characterized. We analyzed demographic and regional disparities in appendicitis-related mortality in the United States from 1999 to 2020 using CDC WONDER data.
methodsWe performed a retrospective analysis of death-certificate data for individuals aged ≥ 25 years, identifying appendicitis-related deaths (ICD-10 K35-K37). Age-adjusted mortality rates (AAMRs) per 100,000 population were standardized to the 2000 U.S. STANDARD: Joinpoint regression estimated annual percentage changes (APCs) and average APCs (AAPCs) with 95% confidence intervals. Analyses were stratified by sex, race/ethnicity, urbanization, and state.
resultsFrom 1999 to 2020, 15,243 appendicitis-related deaths occurred (6643 females and 8600 males). Overall AAMR declined from 0.38 to 0.32 per 100,000 (AAPC -1.38% and 95% CI -3.10 to 0.36). A significant decrease occurred from 1999 to 2018 (APC-2.81% and p < 0.0001), followed by a nonsignificant rise. Males exhibited a consistent decline (AAPC -2.88% and p < 0.0001), whereas females experienced an increase from 2016 to 2020 (APC +5.94% and p < 0.0001). Black individuals had the highest AAMR (0.38) but a significant decline (AAPC -3.73% and p < 0.0001) compared to Whites (AAPC -2.49% and p < 0.0001) and Hispanics (AAPC -2.06% and p < 0.0001). Nonmetropolitan areas had higher AAMR (0.34) than metropolitan areas (0.31). Vermont and New Mexico recorded the highest state-level AAMRs; New Jersey and Louisiana had the lowest.
conclusionsAppendicitis-related mortality in the United States declined over two decades; however, rising mortality among females since 2016 and persistent racial and regional disparities underscore the need for targeted interventions to ensure equitable access to timely surgical care.
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