Evidence map›Paper›PMID 40721894›Full record

ArticleMolecular psychiatry2025

Perinatal omega-3 sex-selectively mitigates neuropsychiatric impacts of prenatal THC in the cortico-striatal-hippocampal circuit.

Mohammed H Sarikahya, Samantha L Cousineau, Marta De Felice, Hanna J Szkudlarek, Kendrick Lee, Aleksandra Doktor, Amanda Alcaide, Marieka V DeVuono, Anubha Dembla, Karen Wong and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mohammed H SarikahyaAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0002-5511-2638
Samantha L CousineauDepartments of Chemistry and Biochemistry, Western University, London, ON, N6A 3K7, Canada.
Marta De FeliceAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Hanna J SzkudlarekAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Kendrick LeeDepartment of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Aleksandra DoktorDepartments of Chemistry and Biochemistry, Western University, London, ON, N6A 3K7, Canada.
Amanda AlcaideAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0009-0007-8217-2971
Marieka V DeVuonoAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0009-0008-9938-0993
Anubha DemblaAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0009-0006-8921-7020
Karen WongAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0009-0003-7679-2868
Mathanke BalarajahAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Sebastian VaninDepartment of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Miray YoussefAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Kuralay ZhaksylykAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Madeline MachadoAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Haseeb MahmoodAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Susanne SchmidDepartment of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0001-5366-8061
Ken K-C YeungDepartments of Chemistry and Biochemistry, Western University, London, ON, N6A 3K7, Canada.ORCID http://orcid.org/0000-0001-6933-2941
Daniel B HardyDepartment of Anatomy and Cell Biology, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.ORCID http://orcid.org/0000-0001-5445-273X
Walter RushlowAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada.
Steven R LavioletteAddiction Research Group, Schulich School of Medicine & Dentistry, Western University, London, ON, N6A 5C1, Canada. steven.laviolette@schulich.uwo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal Δ9-tetrahydrocannabinol exposure (PTE) poses long-lasting neuropsychiatric risks, as evidenced by clinical and preclinical studies, yet the neurobiological mechanisms remain poorly defined. Emerging evidence implicates the neurolipidome, a critical mediator of neurodevelopment and endocannabinoid signaling, as a potential contributor. Here, we demonstrate that dietary omega-3 fatty acid supplementation sex-selectively ameliorates neurodevelopmental deficits induced by PTE in a Wistar rat model. Omega-3 supplementation reduced cognitive and emotional disturbances in male offspring and normalized many neuronal and neurochemical abnormalities in the prefrontal cortex, nucleus accumbens, and ventral hippocampus. However, lipidomic analyses, regardless of omega-3 supplementation, uncovered pronounced, sex-specific PTE-induced disruptions in pathways critical for synaptic integrity and neurodevelopment, including those related to the endocannabinoid system. These findings provide new insights into the interplay between lipid metabolism and the endocannabinoid system in the context of PTE.

Indexed as

DronabinolFatty Acids, Omega-3Prenatal Exposure Delayed EffectsAnimalsCorpus StriatumDisease Models, AnimalEndocannabinoidsFemaleHippocampusMaleNucleus AccumbensPrefrontal CortexPregnancyRatsRats, WistarDronabinolEndocannabinoidsFatty Acids, Omega-3

Identifiers

PMID40721894
PMCPMC12532601

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.