ArticleMolecular biology reports2025
Protocatechuic acid modulates the circadian rhythm of keratinocytes and maintains skin barrier integrity.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multi-Target Anti-Psoriatic Effects ofMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundCircadian rhythms are intrinsic 24-h biological cycles that regulate key physiological processes, including skin cell proliferation, DNA repair, and barrier homeostasis. Disruption of these rhythms accelerates skin aging, compromises barrier integrity, and increases susceptibility to oxidative stress. Protocatechuic acid (PCA) is a naturally occurring compound with antioxidant and anti-inflammatory properties; however, its role in regulating circadian rhythms has not been previously explored. Therefore, this study aimed to investigate the potential of PCA to regulate the circadian rhythm within keratinocytes and the broader effects of PCA on skin physiology. METHODS AND
resultsThis potential of PCA as a circadian rhythm modulator in human epidermal keratinocytes was investigated. PCA enhanced circadian activity in a dose-dependent manner, as evidenced by increased amplitude of basic helix-loop-helix ARNT like 1 (BMAL1)-driven bioluminescence. In silico docking revealed strong binding affinity of PCA to retinoic acid-related orphan receptor alpha (RORα), a core clock regulator, suggesting a molecular mechanism of action. PCA also modulated core clock gene expression. Under oxidative stress conditions, PCA reduced reactive oxygen species (ROS) levels and upregulated antioxidant enzymes, including catalase and superoxide dismutase 1. Additionally, PCA promoted skin barrier integrity by increasing structural protein and ceramide-related gene expression and enhanced cellular longevity markers, such as cyclin-dependent kinase inhibitor 1B (CDKN1B) and telomerase reverse transcriptase (TERT).
conclusionsThese findings demonstrate that PCA functions as a multifunctional agent that modulates circadian rhythms, reduces oxidative stress, and supports skin barrier homeostasis and cellular longevity. Overall, PCA shows strong potential as a therapeutic candidate for treating skin disorders associated with circadian disruption and oxidative damage.
Indexed as
Identifiers
40721875What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.