Evidence map›Paper›PMID 40721842›Full record

ArticleActa neuropathologica communications2025

Mitochondrial dysfunction mediated by ER-calcium dysregulation in neurons derived from Alzheimer's disease patients.

Sarah Mustaly-Kalimi, Wacey Gallegos, Daniel Steinbrenner, Smriti Gupta, Aiden J Houcek, David A Bennett, Robert A Marr, Daniel A Peterson, Israel Sekler, Grace E Stutzmann

Abstract read
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sarah Mustaly-KalimiCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
Wacey GallegosCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
Daniel SteinbrennerCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
Smriti GuptaCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
Aiden J HoucekCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Robert A MarrCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
Daniel A PetersonCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA.
Israel SeklerDepartment of Physiology and Cell Biology, Faculty of Health Science and Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Grace E StutzmannCenter for Neurodegenerative Disease and Therapeutics, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60064, USA. grace.stutzmann@rosalindfranklin.edu.

Funding

Septhohippocamal connectome dysfunction in Down syndrome associated with Alzheimer’s disease pathophysiologyRF1AG077103 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GINSBERG, STEPHEN D, STUTZMANN, GRACE E. · 2023 to 2023
$2.5M
Intracellular organelle deficits driving Alzheimer's diseaseR01AG065628 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI SEKLER, ISRAEL, STUTZMANN, GRACE E. · 2024 to 2024
$431k
Utilizing gene-level biomarkers of AD to identify pathophysiological mechanisms in human neuronsR21AG083638 · NIA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI POTASHKIN, JUDITH ANN, STUTZMANN, GRACE E. · 2023 to 2023
$423k
National Institutes of Health, United States AG077103National Institutes of Health, United States R01AG065628NIA NIH HHS R01 AG065628NIA NIH HHS R21 AG083638NIA NIH HHS RF1 AG077103NIH HHS AG083638
6 · The paper itself

Abstract

Tight regulation of mitochondrial Ca

Indexed as

Alzheimer DiseaseCalciumEndoplasmic ReticulumMitochondriaNeuronsAgedAged, 80 and overCalcium SignalingFemaleHEK293 CellsHumansMaleMiddle AgedRyanodine Receptor Calcium Release ChannelCalciumRyanodine Receptor Calcium Release ChannelAlzheimer’s diseaseCalcium dysregulationiPSC-derived neuronsMitochondriaRyanodine receptor

Identifiers

PMID40721842
PMCPMC12305934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.