Evidence map›Paper›PMID 40721825›Full record

ArticleJournal of eating disorders2025

Using network analysis to personalize treatment for individuals with co-occurring restrictive eating disorders and suicidality: a proof-of-concept study.

Lauren M Harris, Irina A Vanzhula, Elizabeth D Cash, Cheri A Levinson, April R Smith

Abstract read
In one paragraph

Article in Journal of eating disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lauren M HarrisDepartment of Psychological Sciences, Auburn University, 226 Thach Hall, Auburn, AL, 36849-9027, USA. lmh0159@auburn.edu.
Irina A VanzhulaDepartment of Psychological and Brain Sciences, University of Louisville, Louisville, KY, USA.
Elizabeth D CashDepartment of Psychological and Brain Sciences, University of Louisville, Louisville, KY, USA.
Cheri A LevinsonDepartment of Psychological and Brain Sciences, University of Louisville, Louisville, KY, USA.
April R SmithDepartment of Psychological Sciences, Auburn University, 226 Thach Hall, Auburn, AL, 36849-9027, USA.

Funding

Longitudinal Personalized Dynamics Among Anorexia Nervosa Symptoms, Core Dimensions, and Physiology Predicting Suicide RiskR01MH131633 · NIMH · UNIVERSITY OF LOUISVILLE · PI Cheri Alicia Levinson, April Rose Smith · 2023 to 2026
$3.0M
National Institutes of Mental Health 1R01MH131633-01A1NIMH NIH HHS R01 MH131633
6 · The paper itself

Abstract

backgroundNomothetic (i.e., on average) eating disorder interventions generally provide insufficient guidance for managing suicidality. The present proof-of-concept study demonstrates how idiographic network models can be used to inform a modular, highly personalized approach to treatment for individuals experiencing suicidality in the context of Anorexia Nervosa spectrum disorders (ANSD).

methodsUsing 21 days of ecological momentary assessment data (105 assessment points), contemporaneous and temporal idiographic symptom networks were generated for three patients with unique clinical presentations of ANSD. For each patient, we identify the most central symptoms in their network, as well as potentially important bridge symptoms linking eating pathology and suicidality. We then provide guidelines for using this information to guide the delivery of evidence-based intervention strategies.

resultsIntervention strategies may vary substantially depending upon which network statistics are used to guide treatment target selection. Bridge symptoms, or symptoms that serve as links between eating pathology and suicidality, may represent particularly promising intervention targets for individuals experiencing these conditions concurrently. Interventions which target the symptoms with the highest strength centrality may also yield symptom improvement throughout the entire network.

conclusionsAlthough the viability of network-informed, personalized treatment is contingent upon continued intervention development research, this approach has the potential to improve treatment outcomes for individuals with co-occurring eating disorders and suicidality.

Indexed as

Eating disordersIdiographicNetwork analysisPrecision psychiatrySuicide

Identifiers

PMID40721825
PMCPMC12306141

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.