Evidence map›Paper›PMID 40721803›Full record

ArticleScandinavian journal of trauma, resuscitation and emergency medicine2025

Use of the HOPE score to assess survival outcome of hypothermic cardiac arrest selected by ECLS rewarming.

Nicolas Hall, Jessika Métrailler-Mermoud, Valentin Rousson, Chloé Conforti, Amélie Dupasquier, Pierre-Nicolas Carron, Silke Grabherr, Bettina Schrag, Matthias Kirsch, Cheyenne Falat and 3 more

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Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Accidental hypothermia.Nature reviews. Disease primers · 2026
    Review
  2. Review
  3. Emergency care for avalanche buried patients - a narrative review.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nicolas HallDepartment of Emergency Medicine, Lausanne University Hospital and University of Lausanne, BH09, 1011, Lausanne, Switzerland.
Jessika Métrailler-MermoudEmergency Service, Valais Hospital, 1951, Sion, Switzerland.
Valentin RoussonCenter for Primary Care and Public Health (Unisanté), Lausanne, Switzerland.
Chloé ConfortiLausanne University School of Medicine, Lausanne, Switzerland.
Amélie DupasquierLausanne University School of Medicine, Lausanne, Switzerland.
Pierre-Nicolas CarronDepartment of Emergency Medicine, Lausanne University Hospital and University of Lausanne, BH09, 1011, Lausanne, Switzerland.
Silke GrabherrUniversity Center of Legal Medicine, Lausanne - Geneva, Lausanne University Hospital and University of Lausanne, Geneva University Hospital and University of Geneva, Geneva, Switzerland.
Bettina SchragLegal Medicine Service, Hospitals Central Institute (ICH), Sion, Switzerland.
Matthias KirschDepartment of Cardiac Surgery, Lausanne University Hospital, Lausanne, Switzerland.
Cheyenne FalatDepartment of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Dominique DelayDepartment of Cardiac Surgery, Valais Hospital, 1951, Sion, Switzerland.
Vincent FrochauxEmergency Service, Valais Hospital, 1951, Sion, Switzerland.
Mathieu PasquierDepartment of Emergency Medicine, Lausanne University Hospital and University of Lausanne, BH09, 1011, Lausanne, Switzerland. mathieu.pasquier@chuv.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe studied adult hypothermic cardiac arrest (CA) patients admitted to a University Hospital (UH) and a Regional Hospital (RH) for whom Extracorporeal Life Support (ECLS) was implemented. We used the HOPE score to estimate individual survival probabilities and to compare overall results between hospitals.

methodsWe included hypothermic CA patients who underwent ECLS between 2000 and 2022. We assessed the predicted survival probabilities by calculating the HOPE scores, both at individual and hospital levels. We assessed the performance of a HOPE score cutoff of 10% in predicting survival to hospital discharge, as ECLS rewarming is currently recommended when the HOPE is ≥ 10%. We also assessed the utility of the HOPE score in evaluating and comparing patient management within and between two hospitals.

resultsIn the 46 patients with successful ECLS implementation, a HOPE score < 10% would have contraindicated and therefore prevented futile ECLS rewarming procedures for 17 patients (37%) who did not survive, while finding that ECLS was indicated for 100% of survivors. The observed survival rate was 24% (UH: 35%, RH: 11%) whereas the HOPE score predicted a survival rate of 35% (UH: 41%, RH: 26%), suggesting underperformance of ECLS rewarming among both hospitals. The difference of survival between the two hospitals was not statistically significant.

conclusionsThis study confirmed the utility of the HOPE score in estimating individual survival probabilities. The HOPE score may also be used to estimate the overall survival rate in a patient cohort, enabling internal quality-control and outcome results comparisons between different settings.

Indexed as

Extracorporeal Membrane OxygenationHeart ArrestHypothermiaRewarmingAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSurvival RateAccidental hypothermiaBenchmarkingCardiac arrestECLSEnvironmental hypothermiaHOPE score

Identifiers

PMID40721803
PMCPMC12305985

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