ArticleInternational journal of health geographics2025
Ecological epidemiology insights into clonorchiosis endemicity in Guangxi, China and Vietnam: a comprehensive machine learning analysis.
Article in International journal of health geographics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundClonorchis sinensis, the liver fluke responsible for clonorchiosis, presents a persistent public health burden in Guangxi (Southern China) and Vietnam. Its transmission is influenced by a complex interplay of ecological, climatic, and socio-cultural factors.
methodsWe compiled infection occurrence data from systematic literature reviews and national surveys conducted between 2000 and 2018. Environmental and climatic predictors were obtained from long-term raster datasets. Machine learning models, including logistic regression and tree-based ensemble methods, were used to assess associations between predictor variables and C. sinensis presence. Partial dependence plots were employed to refine predictor selection and explore marginal effects.
resultsRaw freshwater fish consumption was identified as the most influential predictor. In Guangxi, 54.9% of counties reported raw fish consumption, compared to 31.7% in Vietnam. Logistic regression achieved the highest predictive accuracy (AUC = 0.941). Climatic comparisons showed that Vietnam had a higher annual mean temperature (Bio1: 23.37 °C vs. 20.86 °C), greater temperature seasonality (Bio4: 609.33 vs. 464.92), and higher annual precipitation (Bio12: 1731.64 mm vs. 1607.56 mm) than Guangxi, contributing to spatial differences in endemicity. High-risk zones were concentrated along the China-Vietnam border, suggesting the need for geographically targeted interventions.
conclusionThe findings underscore the combined influence of ecological and behavioral factors on C. sinensis transmission. The predictive modeling framework offers valuable insights for surveillance planning and cross-border disease control, reinforcing the role of ecological epidemiology in guiding parasitic disease prevention strategies.
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