ArticleBMC women's health2025
Age-period-cohort analysis of global, regional, and national cervical cancer prevalence trends in women of childbearing age (15-49 years), 1990-2021.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Psychological Assessment of Parenting Stress and Emotional Support: A Moderated Mediation Model of Psychological Distress and Well-Being Among Childbearing-Age Women with Thyroid Cancer.Behavioral sciences (Basel, Switzerland) · 2026Article
- Identification of miR-21-5p and miR-21-3p regulated hub genes and drug repurposing targets in cervical cancer: an integrative computational analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Secular trends in menarche age among Iranian girls: Probit analysis on cross-sectional data of Persian (Shahedieh) cohort.International journal of reproductive biomedicine · 2026Article
- Review
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- Adaptive quadtree-based segmentation of nucleus and cytoplasm in pap-smear images: a lightweight and interpretable approach for automated cytology.Frontiers in artificial intelligence · 2026Article
- Application of a modified MSRE-qPCR method for detecting circulating cell-free DNA methylation in cervical cancer.Frontiers in oncology · 2026Article
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7 authors.
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Abstract
purposeCervical cancer remains a significant global health challenge, particularly among women of childbearing age (15-49 years). Recent data indicate a steady rise in cervical cancer incidence and mortality. This study investigates how age, period, and cohort affect cervical cancer prevalence worldwide from 1990 to 2021, with a focus on regional variations in burden based on the socio-demographic index (SDI).
methodsThe analysis used data from the 2021 Global Burden of Disease (GBD) Study, which provided age-standardized rates of incidence, mortality, disability-adjusted life years, and prevalence across 204 countries. We evaluated the age-standardized prevalence rate (ASPR) of cervical cancer in women aged 15-49 years using Joinpoint regression and an age-period-cohort framework to assess the influence of age, time period, and generational effects.
resultsFrom 1990 to 2021, the global ASPR for cervical cancer increased from 91.60 per 100,000 (95% UI: 86.20-97.40) to 105.00 per 100,000 (95% UI: 96.40-114.00). The total number of cases worldwide increased from 1.23 million (95% UI: 1.15-1.30) in 1990 to 2.05 million (95% UI: 1.88-2.23) in 2021. Using Joinpoint regression, we identified distinct trends in ASPR among women aged 15-49 years over the study period, with varying patterns of increase or decline across regions with different SDI levels, reflecting complex socioeconomic and healthcare influences. The highest prevalence was found in women aged 40-44 years, with this age group exhibiting the peak prevalence. The cohort effects had the most significant impact in middle-SDI and lower-SDI regions due to disparities in healthcare infrastructure and prevention efforts.
conclusionsThe rising global prevalence of cervical cancer highlights the growing challenge this disease presents, particularly in low-resource settings, where significant difficulties remain. Our age-period-cohort analysis highlights significant regional variations, emphasizing the need for enhanced access to HPV vaccination and screening, particularly in lower-SDI regions. This study underscores the critical necessity for global efforts to reduce cervical cancer rates and strengthen preventive healthcare measures.
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