Evidence map›Paper›PMID 40721770›Full record

ArticleBMC pulmonary medicine2025

Clinical characteristics of patients with acute pulmonary embolism complicated with antiphospholipid syndrome: a case control study.

Jianyuan Wan, Shuanglan Xu, Jingchao Yang, Qian Liu, Rongping Yang, Wei Kang, Jiao Yang, Xiqian Xing

Abstract read
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In one paragraph

Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Jianyuan Wan *Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Shuanglan Xu *Department of Pulmonary and Critical Care Medicine, Key Laboratory of Respiratory Disease Research of Department of Education of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, China.
Jingchao Yang *Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Qian LiuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Rongping YangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Wei KangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Jiao YangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. yangjiao@kmmu.edu.cn.
Xiqian XingDepartment of Pulmonary and Critical Care Medicine, Key Laboratory of Respiratory Disease Research of Department of Education of Yunnan Province, The Affiliated Hospital of Yunnan University, Kunming, Yunnan, China. xingxiqian@ynu.edu.cn.

Funding

Famous Doctors of High level Talent Training Support Program of Yunnan Province No. YNWR-MY-2020-013; No. XDYC-YLWS-2023-0043the National Natural Science Foundation of China No. 82160016the Special and Joint Program of the Yunnan Provincial Science and Technology Department and Kunming Medical University No. 202201AY070001-265; No. 202301AY070001-189Yunnan Provincial Innovation Team for Respiratory and Pulmonary Circulation Diseases No. 202405AS350018
6 · The paper itself

Abstract

objectiveAcute pulmonary embolism (APE) is a critical and severe respiratory disease with a high mortality rate. Antiphospholipid syndrome (APS) is a risk factor for the occurrence and recurrence of pulmonary thromboembolism. This study explored the clinical characteristics of patients with APS combined with APE (APS-APE).

methodsSixty-eight patients with APS were retrospectively enrolled in the study, among which 34 patients suffered from APS-APE, and another 34 patients did not. Age and gender were matched between the groups. The clinical data of patients were collected. The clinical characteristics of the 2 groups were summarized and analysed by comparing the clinical data.

results61.8% patients of APS-APE had a history of lower limbs deep venous thrombosis (DVT), which was more common than APE group. The first symptoms of patients in APS-APE group were more common than APS group when admitted to hospital, including cough, fever, dyspnea, hemoptysis, chest tightness, chest pain, swelling and pain of lower limbs. The level of both D-dimer and fibrinogen degradation products (FDP) in APS-APE group was higher than APS group. The positive detection rate of aβ2GPI in APS-APE group had a higher level. Binary logistic regression analysis showed that the risk factors of APE in APS patients were dyspnea, positive aβ2GPI and elevated D-dimer.

conclusionsAPS patients with medical history of DVT and with abnormal results of D-dimer, FDP and aβ2GPI were more likely to be suffered from APE. Dyspnea, positive aβ2GPI and elevated D-dimer are risk factors for APE in APS patients.

Indexed as

Antiphospholipid SyndromeFibrin Fibrinogen Degradation ProductsPulmonary EmbolismVenous ThrombosisAdultAgedbeta 2-Glycoprotein ICase-Control StudiesChest PainCoughDyspneaFemaleFeverHemoptysisHumansMalebeta 2-Glycoprotein IFibrin Fibrinogen Degradation Productsfibrin fragment DAcute pulmonary embolismAntiphospholipid syndromeClinical featuresRisk factors

Identifiers

PMID40721770
PMCPMC12302800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.