Evidence map›Paper›PMID 40721675›Full record

ReviewNature neuroscience2025

A neural manifold view of the brain.

Matthew G Perich, Devika Narain, Juan A Gallego

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
  2. Structure Guides Function: Beyond Pairwise Neural Interactions.The Journal of comparative neurology · 2026
    Review
  3. Article
  4. Article
  5. Neural manifold connectomics reveals multiregime functional connectivity.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Refinement of Nucleus Accumbens Neuronal Dynamics during Cocaine Self-Administration Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Re-engineering the disordered mind: clinical experimentation, dynamical systems, and AI for personalized psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew G PerichDépartement de neurosciences, Faculté de médecine, Université de Montréal, Montreal, Quebec, Canada. matthew.perich@umontreal.ca.ORCID http://orcid.org/0000-0001-9800-2386
Devika NarainDepartment of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0001-7249-1273
Juan A GallegoDepartment of Bioengineering, Imperial College London, London, UK. jgallego@imperial.ac.uk.ORCID http://orcid.org/0000-0003-2146-0703

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-2020-StG-949660Fonds de Recherche du Québec - Santé (Fonds de la recherche en sante du Quebec) chercheurs-boursiers en intelligence artificielleNederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) Gravitation - DBI2 - 024.005.022Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) NWO Vidi - VI.Vidi.193.076RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/T020970/1
6 · The paper itself

Abstract

Animal behavior arises from the coordinated activity of neural populations that span the entire brain. The activity of large neural populations from an increasing number of brain regions, behaviors and species shows low-dimensional structure. We posit that this structure arises as a result of neural manifolds. Neural manifolds are mathematical descriptions of a meaningful biological entity: the possible collective states of a population of neurons given the constraints, both intrinsic (for example, connectivity) and extrinsic (for example, behavior), to the neural circuit. Here, we explore the link between neural manifolds and behavior, and discuss the insights that the neural manifold framework can provide into brain function. To conclude, we explore existing conceptual gaps in this framework and discuss their implications when building an integrative view of brain function. We thus position neural manifolds as a crucial framework with which to describe how the brain generates behavior.

Indexed as

BrainModels, NeurologicalNerve NetNeuronsAnimalsHumansNeural Pathways

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.