Evidence map›Paper›PMID 40721664›Full record

ReviewAnnals of medicine2025

Therapeutic potential of plant-derived exosome-like nanoparticles for CNS diseases: advancements in preparation and characterization.

Mengmeng Liu, Hongli Wang, Yizhuang Yang, Jianhua Wang, Zhen Sun, Shiyuan Zhao, Weihua Kong, Wenxue Sun, Cuiyun Wang, Lei Feng

Abstract readReview
In one paragraph

Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengmeng LiuDepartment of Pharmacy, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, China.
Hongli WangDepartment of Pharmacy, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, China.
Yizhuang YangDepartment of Pharmacy, Guilin Medical University, Guilin, China.
Jianhua WangShandong University of Traditional Chinese Medicine, Jinan, China.ORCID 0000-0002-2858-6029
Zhen SunTranslational Pharmaceutical Laboratory, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, China.
Shiyuan ZhaoTranslational Pharmaceutical Laboratory, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, China.
Weihua KongDepartment of Neurosurgery, Jining No.1 People's Hospital, Shandong First Medical University, Jining, China.
Wenxue SunShandong University of Traditional Chinese Medicine, Jinan, China.ORCID 0000-0003-4998-5296
Cuiyun WangDepartment of Pharmacy, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, China.
Lei FengDepartment of Neurosurgery, Jining No.1 People's Hospital, Shandong First Medical University, Jining, China.ORCID 0000-0002-4638-4164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KEY MESSAGESPDELNs are derived from abundant plant sources, exhibit favorable physicochemical properties.PDELNs offer new possibilities for CNS therapies owing to their low immunogenicity, high biocompatibility, and ability to cross the BBB.

Indexed as

Central Nervous System DiseasesExosomesNanoparticlesAnimalsBlood-Brain BarrierDrug Delivery SystemsHumansCNS diseasesdrug delivery systemsExosomesplant-derived exosome-like nanoparticles

Identifiers

PMID40721664
PMCPMC12305875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.