Evidence map›Paper›PMID 40721635›Full record

ArticleCommunications biology2025

PPP6R3-mediated dephosphorylation regulates mRNA translation during spermatogonial differentiation.

Qian Fang, Biyun Liu, Jie Cen, Tongtong Li, Shuhui Ji, Wenqing Li, Gang Lu, Zi-Jiang Chen, Xin Wang, Jianqiang Bao and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qian Fang *Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.
Biyun Liu *Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.
Jie CenInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.
Tongtong LiInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.
Shuhui JiState Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Wenqing LiCenter for Reproduction and Genetics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.ORCID http://orcid.org/0009-0000-6591-9059
Gang LuCUHK-SDU Joint Laboratory on Reproductive Genetics, School of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong, 999077, China.
Zi-Jiang ChenInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. chenzijiang@hotmail.com.ORCID http://orcid.org/0000-0001-6637-6631
Xin WangKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, Zhejiang, China. wx@ucas.ac.cn.ORCID http://orcid.org/0000-0003-3807-9319
Jianqiang BaoCenter for Reproduction and Genetics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. jqbao@ustc.edu.cn.ORCID http://orcid.org/0000-0003-1248-2687
Hongbin LiuInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China. hongbin_sduivf@aliyun.com.ORCID http://orcid.org/0000-0003-2550-7492

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein dephosphorylation mediated by phosphatases regulates spermatogenesis. However, which proteins are dephosphorylated and how they regulate spermatogenesis are largely unknown. Here, we show that germline-specific deletion of protein phosphatase 6 regulatory subunit 3 (PPP6R3), which determines substrate specificity of protein phosphatase 6 (PP6), causes abnormal spermatogonial differentiation and male infertility, accompanied by translation inhibition. PPP6R3 directly interacts with EIF3C and EIF4G1 in KIT

Indexed as

Cell DifferentiationPhosphoprotein PhosphatasesProtein BiosynthesisRNA, MessengerSpermatogenesisSpermatogoniaAnimalsEukaryotic Initiation Factor-4GMaleMiceMice, KnockoutPhosphorylationEukaryotic Initiation Factor-4GPhosphoprotein Phosphatasesprotein phosphatase 6RNA, Messenger

Identifiers

PMID40721635
PMCPMC12304272

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.