ArticleScientific reports2025
Infant rat ultrasonic vocalizations in the neurodevelopmental model of schizophrenia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Social deprivation weakens sender-receiver coupling in mother-infant acoustic communication by altering pup vocal development in Mongolian gerbils (Meriones unguiculatus).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Maternal exposure to titanium dioxide nanoparticles disrupts ultrasonic vocalization development in mouse offspring.Particle and fibre toxicology · 2026Article
- Developmental trajectories of vocal behaviors in common marmosets as a reference framework for neurobehavioral studies.Frontiers in neural circuits · 2026Article
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4 authors.
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Abstract
Schizophrenia is characterized by early brain developmental abnormalities resulting in, among others, compromised communication. Rodent models, such as prenatal exposure to methylazoxymethanol acetate (MAM), help investigate schizophrenia-related deficits. Ultrasonic vocalizations (USVs) in rodent pups are a preclinical tool to study social communication. This study examines how prenatal MAM exposure affects the development, structure, and maternal potentiation of USVs. Pregnant rats received MAM or saline on the 17th gestational day. Offspring USVs were recorded upon maternal separation on the 6th, 9th, and 12th postnatal days (PND), while maternal potentiation was tested on the 10th PND. USV characteristics, temporal organization, clustering, and syntax were analyzed by DeepSqueak's machine-learning algorithms. Unlike controls, which showed an increasing USV rate associated with proper vocal development, MAM-exposed pups displayed a stable emission rate across days and emitted fewer USVs on the 12th PND. Maternal potentiation was weak or absent in MAM pups, which also exhibited lower call complexity (reduced bandwidth and frequency) and longer duration. Temporal analysis revealed delayed vocal onset, prolonged inter-call intervals, and disrupted call arrangement. Syntax analysis indicated a simplified transition pattern dominated by low-pitched flat calls. Taken together, prenatal MAM exposure disrupts vocal communication, leading to less complex vocalizations with altered timing and structure. These deficits may serve as early markers of negative-like symptoms or cognitive dysfunctions in schizophrenia.
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