Evidence map›Paper›PMID 40721598›Full record

ReviewCell death & disease2025

Emerging roles of epigenetic regulators during lung development.

Guohua Meng, Wenli Yin, Yue Hong, Salvatore Oliviero

Abstract readReview
In one paragraph

Review in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guohua MengSchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.ORCID http://orcid.org/0000-0002-6407-4776
Wenli YinSchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China.
Yue HongSchool of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of Life and Health, Hainan University, Haikou, Hainan, China. yuehongsls@hainanu.edu.cn.ORCID http://orcid.org/0000-0002-9866-0589
Salvatore OlivieroDepartment of Life Sciences and Systems Biology, University of Turin, Torino, Italy. salvatore.oliviero@unito.it.ORCID http://orcid.org/0000-0002-3405-765X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82270002
6 · The paper itself

Abstract

Epigenetic pathways, including DNA methylation, non-coding RNAs, histone modification, and chromatin remodeling, control spatiotemporal gene expression and tightly coordinate the activities during embryogenesis. Emerging evidence indicates that epigenetic regulators are critically required for the maintenance of normal lung development and that the epigenetic marks are altered in lung cells during disease progression. In this review, we focus on the recent studies that have yielded insights into how the levels and patterns of epigenetic regulators are changed, and how these regulators contribute to the regulation of various stages during lung development. A deeper understanding of these epigenetic mechanisms could offer novel therapeutic targets for preventing fetal lung diseases.

Indexed as

Epigenesis, GeneticLungAnimalsChromatin Assembly and DisassemblyDNA MethylationGene Expression Regulation, DevelopmentalHistonesHumansHistones

Identifiers

PMID40721598
PMCPMC12304124

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.