Evidence map›Paper›PMID 40721590›Full record

ArticleScientific reports2025

Risk of Long COVID in hospitalized individuals treated with remdesivir for acute COVID-19.

Mark Berry, Amanda M Kong, Roger Paredes, Julie Paone, Rohan Shah, Rebecca Taylor, Essy Mozaffari, Rikisha Gupta, Robert L Gottlieb, Lourdes Mateu and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Evaluating treatment effectiveness: Complementing RCTs with real-world data.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2026
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mark BerryGilead Sciences, Inc., Foster City, CA, USA.
Amanda M KongAetion, Inc., 5 Penn Plaza, New York, NY, USA.
Roger ParedesIrsiCaixa, Ctra. de Canyet, Barcelona, Spain.
Julie PaoneAetion, Inc., 5 Penn Plaza, New York, NY, USA.
Rohan ShahAetion, Inc., 5 Penn Plaza, New York, NY, USA.
Rebecca TaylorAetion, Inc., 5 Penn Plaza, New York, NY, USA.
Essy MozaffariGilead Sciences, Inc., Foster City, CA, USA.
Rikisha GuptaGilead Sciences, Inc., Foster City, CA, USA.
Robert L GottliebBaylor University Medical Center, Dallas, TX, USA.
Lourdes MateuDepartment of Infectious Diseases, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain.
Mazin AbdelghanyGilead Sciences, Inc., Foster City, CA, USA.
Jason D GoldmanSwedish Center for Research and Innovation, Providence Swedish Medical Center, Seattle, WA, USA. Jason.Goldman@swedish.org.
Anand P ChokkalingamGilead Sciences, Inc., Foster City, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long COVID comprises a multisystem syndrome occurring after COVID-19. This retrospective cohort study investigated whether remdesivir given during acute COVID-19 is associated with reduced incidence of Long COVID, including in immunocompromised subgroups. The HealthVerity database of hospital chargemaster data linked to closed claims was queried for patients aged ≥ 12 years hospitalized for ≥ 2 days with COVID-19 between May 1, 2020, and September 30, 2021. Relative risk between remdesivir-exposed and unexposed patients was calculated for 16 individual Long COVID outcomes and a composite of any Long COVID outcome, occurring 90-270 days after hospital admission. Subgroup analyses occurred in immunocompromised patients. Regression models accounted for censoring, competing risks, and treatment assignment weights; statistical inferences were adjusted for multiple comparisons. Among 3,661,303 hospitalized patients, 52,006 with COVID-19 were included; 20,246 (38.9%) were immunocompromised. In the overall and immunocompromised populations, respectively, 33.0% and 29.5% received remdesivir; the composite of ≥ 1 Long COVID outcome occurred in 55.5% and 62.9%. Patients administered remdesivir experienced lower risk of any Long COVID outcome (risk ratio, 0.96; 95% CI 0.94-0.97; adjusted P < 0.001). Risk for several individual Long COVID outcomes was lower in those receiving remdesivir in the overall and immunocompromised populations. In conclusion, exposure to remdesivir was associated with a lower risk of Long COVID.

Indexed as

Adenosine MonophosphateAlanineAntiviral AgentsCOVID-19COVID-19 Drug TreatmentAdolescentAdultAgedAged, 80 and overFemaleHospitalizationHumansImmunocompromised HostMaleMiddle AgedRetrospective StudiesAdenosine MonophosphateAlanineAntiviral AgentsremdesivirAntiviral therapyCOVID-19Immunocompromising conditionsLong COVIDRemdesivir

Identifiers

PMID40721590
PMCPMC12304269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.