Evidence map›Paper›PMID 40721582›Full record

ArticleNature communications2025

A dedicated skin-to-brain circuit for cool sensation in mice.

Hankyu Lee, Chia Chun Hor, Lorraine R Horwitz, Ailin Xiong, Xin-Yu Su, Daniel R Soden, Sarah Yang, Wei Cai, Wenwen Zhang, Chen Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hankyu Lee *Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-0949-3345
Chia Chun Hor *Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Lorraine R Horwitz *Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Ailin XiongDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Xin-Yu SuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Daniel R SodenDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Sarah YangDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Wei CaiLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Wenwen ZhangLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Chen LiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Christopher RadcliffDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Abbey DinhDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Tin Long Rex FungDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1526-0203
Ilma RovcaninDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Kevin P PipeDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
X Z Shawn XuLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7102-5035
Bo DuanDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. bduan@umich.edu.ORCID http://orcid.org/0000-0001-7915-8537

Funding

TRAINING PROGRAM IN CELL AND MOLECULAR DERMATOLOGYT32AR007197 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JAMES TILFORD ELDER, Sunny Y Wong · 1986 to 2026
$4.2M
An unexpected role of glutamate receptors in the peripheral nervous systemR01NS118769 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO, XU, SHAWN · 2020 to 2024
$2.6M
Dissecting neural circuits for mechanical itchR01NS109170 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO · 2019 to 2023
$2.2M
NIAMS NIH HHS T32 AR007197NINDS NIH HHS R01 NS109170NINDS NIH HHS R01 NS118769U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS109170U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS118769
6 · The paper itself

Abstract

Perception of external temperature is essential for maintaining homeostasis and avoiding thermal injury. Although molecular thermosensors such as transient receptor potential melastatin type 8 (TRPM8) have been identified, the neural circuits responsible for transmitting cool signals remain unclear. Here we show that a spinal circuit in mice conveys cool signals from the skin to the brain. Excitatory interneurons in the spinal dorsal horn expressing thyrotropin-releasing hormone receptor (Trhr

Indexed as

BrainSkinThermosensingAnimalsCold TemperatureFemaleInterneuronsMaleMiceMice, Inbred C57BLParabrachial NucleusTRPM Cation ChannelsTRPM8 protein, mouseTRPM Cation Channels

Identifiers

PMID40721582
PMCPMC12304207

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.