ArticleJournal of nephrology2025
Association of accelerometer-measured physical activity with adverse cardiovascular outcomes in individuals with or without chronic kidney diseases: the UK biobank study.
Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Rethinking exercise targets: sex differences in the road to a longer life.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
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Authors and funding
18 authors.
Funding
Abstract
backgroundPhysical activity is important for health and longevity, but little is known on patients living with chronic kidney disease (CKD). In fact, most studies in patients with CKD have relied on self-reported data, highlighting an unmet need for studies using objective measurements. We investigated the association between device-measured physical activity and adverse outcomes by CKD status.
methodsThis study included 65,088 participants without CKD and 1170 with CKD, from the UK Biobank, who completed a one-week accelerometer assessment. CKD was defined as either baseline estimated glomerualr filtration rate (eGFR) < 60 mL/min/1.73 m
resultsOver a median follow-up period of 8.04 years, all-cause mortality occurred in 2028 (3.06%) participants, with an incidence of 3.84/1000 person-years. Compared with the 1st quartile, the adjusted hazard ratios (95% confidence intervals) for all-cause mortality for the 2nd, 3rd, and 4th quartiles were 0.72 (0.64-0.80), 0.65 (0.57-0.72), and 0.57 (0.49-0.66) in non-CKD, and 0.56 (0.33-0.96), 0.42 (0.23-0.79), and 0.33 (0.16-0.68) in CKD participants. This pattern was consistent for non-cardiovascular deaths. However, device-measured physical activity was not significantly associated with three-point major adverse cardiovascular events in CKD, while a significant association was observed in the non-CKD group.
conclusionDevice-measured physical activity showed differential associations with outcomes by CKD status. The null association between physical activity and three-point major adverse cardiovascular events in CKD suggests a complex cardiovascular pathophysiology in this population.
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