ArticleActa pharmacologica Sinica2026
Copper pyrithione, a copper complex ATG4B and autophagy inhibitor, exhibits potent anticancer effects.
Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A Novel Autophagy InhibitorResearch (Washington, D.C.) · 2026Article
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10 authors.
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Abstract
Inhibition of autophagy has been considered as a promising strategy for tumor therapy, discovery of small-molecule autophagy inhibitors suitable for clinical use would be of great significance. Since cysteine protease ATG4B plays a key role in the autophagy machinery by processing pro-LC3 and lipidated LC3 to drive the autophagy progress, inhibition of ATG4B may serve as a potential therapeutic strategy. We previously found that copper ions instead of other ions efficiently inhibited ATG4B activity, which was more potent than other ATG4B inhibitors reported. As copper ions are easily chelated, copper complexes may develop into novel ATG4B inhibitors. In this study we identified a copper complex antifouling agent, copper pyrithione (CuPT), which effectively inhibited ATG4B activity and blocked autophagy flux. By combining FRET-based assay in vitro and cell-based assays, we showed that CuPT effectively inhibited ATG4B activity with an IC
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