ArticleEye (London, England)2025
Photoreceptor damage in pachychoroid pigment epitheliopathy.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Persistent fluid, persistent risk: predicting pachychoroid macular atrophy in chronic central serous chorioretinopathy.Eye (London, England) · 2026Article
- Pachychoroid pigment epitheliopathy: long-term structural changes and risk factors for disease evolution.Eye (London, England) · 2026Article
- Distinct Pathogenic Mechanisms of Neurodegeneration in Pachychoroid Pigment Epitheliopathy Versus Intermediate Age-Related Macular Degeneration.Ophthalmology and therapy · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the relationship between choriocapillaris perfusion and photoreceptor integrity in pachychoroid pigment epitheliopathy (PPE).
methodsWe compared 44 PPE eyes with 30 healthy controls using swept-source OCT angiography to analyse ellipsoid zone reflectivity, choriocapillaris flow deficit percentage (FD%) and retinal capillary perfusion.
resultsPPE eyes showed significantly reduced EZ reflectivity compared to controls (0.73 ± 0.10 vs 0.79 ± 0.05, p = 0.014), increased choriocapillaris ischemia (CC FD%: 46.6 ± 6.3 vs 32.5 ± 2.9, p < 0.001), and reduced deep capillary plexus perfusion (33.1 ± 4.6 vs 38.6 ± 3.3, p < 0.001). Multiple regression analysis revealed a significant inverse association between increased CC ischemia and reduced EZ reflectivity (r = -0.364, p < 0.001).
conclusionChoriocapillaris ischemia significantly correlates with photoreceptor damage in PPE, suggesting vascular dysfunction as a key pathogenic mechanism.
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