ArticleEye (London, England)2025
Epiretinal membrane formation following laser photocoagulation for peripheral retinal degeneration: incidence and risk factors.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Five-year risk of rhegmatogenous retinal detachment following prophylactic laser retinopexy for retinal breaks and lattice degeneration: a real-world analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Response to: Comment on: "Epiretinal membrane formation and incomplete separation of the posterior hyaloid membrane".Eye (London, England) · 2026Article
- Comment on: 'Epiretinal membrane formation and incomplete separation of the posterior hyaloid membrane'.Eye (London, England) · 2026Article
- Association between peripheral retinal lesions and ocular biometric parameters in adults with mild-to-moderate myopia attending a refractive surgery clinic.Frontiers in medicine · 2026Article
- Encircling Laser Prophylaxis for Retinal Detachment in Stickler Syndrome: The Impact on Visual Field.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- A Historical Review of Encircling Laser Retinopexy as a Prophylaxis for Rhegmatogenous Retinal Detachment; and a Commentary on Recent Progress in Stickler Syndrome.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Can Laser Retinopexy Prevent Retinal Detachment in Asymptomatic, High-Risk Eyes?Clinical ophthalmology (Auckland, N.Z.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLaser photocoagulation remains the most common treatment for peripheral retinal degeneration. However, potential side effects, particularly inflammation and gliosis, raise concerns about an increased risk of epiretinal membrane (ERM) formation. This study aims to further investigate the association between laser photocoagulation and ERM formation and identify associated risk factors.
methodsThis retrospective study included patients who underwent retinal laser photocoagulation for peripheral retinal degeneration. Clinical data including medical history, ophthalmic examinations during follow-up, and details of the laser photocoagulation, were recorded. Binary regression analysis was used to assess risk factors for ERM formation, including age, ocular findings, and laser parameters.
resultsAmong the 726 eyes, 32 eyes (4.41%) developed ERM during a follow-up period of 29.7 ± 17.2 months. Risk factors included older age (53.9 ± 11.1 vs. 36.6 ± 17.3 years, P < 0.001), presence of lattice degeneration (62.5% vs. 40.3%, P < 0.001), greater number of laser spots (390.1 ± 171.9 vs. 284.8 ± 156.4, P < 0.001), higher total laser energy (22.5 ± 10.8J vs. 13.6 ± 11.9J, P < 0.001), wider extent of laser coverage (4.47 ± 3.38 vs. 3.08 ± 2.10 clock hours, P = 0.028), and shorter distance between the laser and the fovea (7.50 ± 1.72 vs. 8.36 ± 2.16 disc diameters, P = 0.017). Further regression analysis identified age (OR 1.071, 95% CI 1.040-1.102), number of laser spots (OR 1.003, 95% CI 1.001-1.005), and extent of laser coverage (OR 1.178, 95% CI 1.025-1.354) as independent risk factors for ERM development.
conclusionsPeripheral retinal laser photocoagulation does not significantly increase the incidence of ERM. However, careful control of the number and extent of laser applications may help minimize potential damage to the macula.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.