The Drosophila DEG/ENaC PPK12 is a Na

Lu Qin, Nikita Komarov, Cornelia Fritsch, Simon G Sprecher, Stefan Gründer, Dominik Wiemuth

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lu QinInstitute of Physiology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

Nikita KomarovDepartment of Biology, University of Fribourg, Chemin du Musée 10, Fribourg, CH-1700, Switzerland.

Cornelia FritschDepartment of Biology, University of Fribourg, Chemin du Musée 10, Fribourg, CH-1700, Switzerland.

Simon G SprecherDepartment of Biology, University of Fribourg, Chemin du Musée 10, Fribourg, CH-1700, Switzerland.

Stefan GründerInstitute of Physiology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. sgruender@ukaachen.de.

Dominik WiemuthInstitute of Physiology, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DEG/ENaC ion channels have various functions in different organisms. In Drosophila, DEG/ENaCs are named Pickpockets (PPKs) and form a large insect-specific radiation with seven subfamilies containing 31 members. Several different functions have been proposed for PPKs, including salt and water taste. However, despite their many functions, most PPKs have not been functionally characterized in heterologous expression systems, leaving their functional properties unknown. Here, we expressed six PPKs in Xenopus oocytes, which are expressed in the chemosensory system of Drosophila larvae. We found that PPK12 forms a constitutively open ion channel that is permeable to Na

Indexed as

Drosophila ProteinsEpithelial Sodium ChannelsSodiumAnimalsDrosophilaDrosophila melanogasterOocytesXenopus laevisDrosophila ProteinsEpithelial Sodium ChannelsSodiumIon channelLarvaeSalt sensationTaste

Identifiers

PMID40721433

DOI10.1016/j.cub.2012.09.019

PMCPMC12304301

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.