Evidence map›Paper›PMID 40721421›Full record

ArticleTranslational psychiatry2025

Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism.

Damien Huzard, Giulia Oliva, Mélanie Marias, Chloé Granat, Vanessa Soubeyre, Glaécia do Nascimento Pereira, Ahmed Negm, Gawain Grellier, Jérôme Devaux, Emmanuel Bourinet and 1 more

Abstract read
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Altered Primary Somatosensory Neuron Development in a Pten Heterozygous Model for Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Damien Huzard *Institut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.ORCID http://orcid.org/0000-0003-4820-7951
Giulia Oliva *Institut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.ORCID http://orcid.org/0009-0006-2026-6027
Mélanie MariasInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.
Chloé GranatInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.
Vanessa SoubeyreInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.
Glaécia do Nascimento PereiraInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.
Ahmed NegmInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.
Gawain GrellierInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.
Jérôme DevauxInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.
Emmanuel BourinetInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France.ORCID http://orcid.org/0000-0001-8021-0419
Amaury FrançoisInstitut de Génomique Fonctionnelle (IGF), Université de Montpellier, CNRS UMR5203, INSERM U1191, Montpellier, France. amaury.francois@igf.cnrs.fr.ORCID http://orcid.org/0000-0003-1171-7974

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-20-NEUR-0001Fédération pour la Recherche sur le Cerveau (FRC) Toucher socialFondation Bettencourt Schueller (Bettencourt Schueller Foundation) Impulscience 2022Fondation Lefoulon Delalande (Lefoulon Delalande Foundation) Research fellowship
6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors and atypical sensory perception. The link between ASD and skin abnormalities, inducing itchiness, has never been investigated in depth. This study explores mechanical itch sensitivity in the Shank3

Indexed as

Autism Spectrum DisorderMechanoreceptorsNerve Tissue ProteinsPruritusAnimalsDisease Models, AnimalMaleMiceMicrofilament ProteinsNerve Fibers, UnmyelinatedSkinMicrofilament ProteinsNerve Tissue ProteinsShank3 protein, mouse

Identifiers

PMID40721421
PMCPMC12304312

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.