Evidence map›Paper›PMID 40721252›Full record

ArticleBMJ open2025

Association between e-cigarette use, physical activity and cardiorespiratory fitness: protocol for a systematic review.

Hayley Thode, Javad Heshmati, Hassan Mir

Abstract read
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hayley ThodeUniversity of Ottawa Heart Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0009-0006-6631-0919
Javad HeshmatiUniversity of Ottawa Heart Institute, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0002-2676-0185
Hassan MirUniversity of Ottawa Heart Institute, Ottawa, Ontario, Canada Hmir@ottawaheart.ca.ORCID http://orcid.org/0000-0002-7486-8123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite the rise in popularity of e-cigarette smoking or 'vaping', its long-term health consequences are still being investigated. In particular, it is unclear what impact e-cigarette use has on aerobic performance and exercise capacity. This information has important implications both for tobacco smokers as a harm reduction approach, and youth and young adults who are increasingly turning to e-cigarettes recreationally. Thus, this review aims to systematically evaluate the literature surrounding the effects of regular e-cigarette use on markers of cardiorespiratory fitness and physical activity. METHODS AND ANALYSIS: This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. A systematic search was undertaken in October 2024, using the defined population, intervention, comparison, outcomes, study time framework to identify all relevant articles. Studies will be eligible if they include individuals who use e-cigarette products, assess regular e-cigarette use as an exposure, compare to a group of non-users and report outcomes related to measures of cardiorespiratory fitness (eg, VO2max, 6 min walk test) or physical activity (eg, sport participation, meeting weekly physical activity guidelines), regardless of study duration. Searched databases will include PubMed/Medline, Cochrane Library and Embase, with no restriction to date or language of publication. Two reviewers will carry out the title and abstract screening, full text review and data extraction. Risk of bias will be assessed using the Newcastle-Ottawa Scale for non-randomised studies and the Cochrane Risk of Bias Tool (v2) for randomised studies. Study heterogeneity will be assessed using the Q and I ETHICS AND DISSEMINATION: Ethics approval is not required for this review of previously published or presented data. The results of the review will be disseminated via conference presentations and peer-reviewed publication. Moreover, results of this review may inform public health recommendations and identify areas in the field where further research is needed. PROSPERO REGISTRATION NUMBER: CRD420250589685.

Indexed as

Cardiorespiratory FitnessElectronic Nicotine Delivery SystemsExerciseVapingHumansResearch DesignSystematic Reviews as TopicCardiovascular DiseaseExercisePhysical FitnessSmoking Reduction

Identifiers

PMID40721252
PMCPMC12306318

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.