Evidence map›Paper›PMID 40720815›Full record

ArticleJMIR research protocols2025

Effect of Dual Bronchodilation on the Exercise Capacity of Individuals With Non-Cystic Fibrosis Bronchiectasis: Protocol for a Randomized Controlled Double-Blind Crossover Study.

Cibele Cristine Berto Marques da Silva, Simone Dal Corso, Adriana Claudia Lunardi, Alfredo José Fonseca, Samia Zahi Rached, Rodrigo Abensur Athanazio, Celso Ricardo Fernandes Carvalho

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05183841 (Effect of Bronchodilators on the Exercise Capacity of Bronchiectasis Patients), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05183841 naunknown statusnot on this map

Effect of Bronchodilators on the Exercise Capacity of Bronchiectasis Patients

TypeinterventionalSponsorUniversity of Sao Paulo General HospitalRan2022 to 2025Enrolled40ConditionsBronchiectasis AdultArmsBronchodilator (Ipratropium and Fenoterol), Placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cibele Cristine Berto Marques da SilvaDepartment of Physical Therapy, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-0615-4070
Simone Dal CorsoDepartment of Allergy, Immunology and Respiratory Medicine, Monash University, Monash, Australia.ORCID 0000-0001-9190-6796
Adriana Claudia LunardiDepartment of Physical Therapy, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-6133-3816
Alfredo José FonsecaMedical Clinic Department, Clinics Hospital, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-8632-5428
Samia Zahi RachedPneumology Department, Heart Institute, University of São Paulo, São Paulo, Brazil.ORCID 0000-0001-6741-1320
Rodrigo Abensur AthanazioPneumology Department, Heart Institute, University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-9399-5275
Celso Ricardo Fernandes CarvalhoDepartment of Physical Therapy, University of São Paulo, São Paulo, Brazil.ORCID 0000-0003-3046-3412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchodilators (BDs) have been used therapeutically to improve exercise capacity in patients with other chronic respiratory diseases. However, the effect of BDs on the exercise capacity of individuals with non-cystic fibrosis bronchiectasis (NCFB) is poorly understood.

objectiveThe aim of this study was to evaluate the effects of BDs on exercise capacity and thoracoabdominal kinematics in patients with NCFB.

methodsThis crossover randomized controlled trial will involve 45 outpatients with NCFB aged 18 to 59 years. They will be evaluated in 3 visits. On day 1, the maximal exercise capacity (cardiopulmonary exercise test; peak work rate [W

resultsThe ethics approval was granted in November 2018, and a pilot study was commenced in April 2019 but was interrupted due to the COVID-19 pandemic. The study restarted in April 2022, and data collection is anticipated to continue until November 2025. The publication of the results is anticipated to be in 2025 or 2026.

conclusionsThere is no evidence that BDs can improve the exercise capacity of patients with NCFB. This trial will compare the endurance exercise capacity of the same individual with and without dual bronchodilation. If successful, this study will demonstrate that exercise capacity can be improved with the use of BDs in adults with NCFB.

trial registrationClinicalTrials.gov NCT05183841; https://clinicaltrials.gov/study/NCT05183841. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/68582.

Indexed as

BronchiectasisBronchodilator AgentsExercise ToleranceAdolescentAdultCross-Over StudiesDouble-Blind MethodExercise TestFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicYoung AdultBronchodilator Agentsbronchiectasisbronchodilator agentsexerciseexercise capacityexercise testnon-cystic fibrosis bronchiectasisthoracoabdominal kinematics

Identifiers

PMID40720815
PMCPMC12340461

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.