Evidence map›Paper›PMID 40720752›Full record

ArticleJournal of travel medicine2025

Revisiting the efficacy of bismuth subsalicylate for the prevention of traveller's diarrhoea.

Roger D Gibb, Jose M Brum, Kyle J Sloan, Adam M Pitz, Benjamin T Circello, Rowan A Grayling

Abstract readComment
In one paragraph

Article in Journal of travel medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Roger D GibbHealthcare Biostatistics, The Procter and Gamble Company, Mason, OH 45040, United States.
Jose M BrumHealthcare Clinical, The Procter and Gamble Company, Mason, OH 45040, United States.
Kyle J SloanHealthcare R&D, The Procter and Gamble Company, Mason, OH 45040, United States.
Adam M PitzHealthcare R&D, The Procter and Gamble Company, Mason, OH 45040, United States.
Benjamin T CircelloHealthcare R&D, The Procter and Gamble Company, Mason, OH 45040, United States.
Rowan A GraylingHealthcare R&D, The Procter and Gamble Company, Mason, OH 45040, United States.

Funding

CDCProcter and GambleThe New York Center for Travel and Tropical Medicine D-129-18-00The New York Center for Travel and Tropical Medicine through a Cooperative Research and Development Agreement D-129-18-00
6 · The paper itself

Abstract

What can be concluded from a clinical trial that spanned 5 years yet failed to achieve target enrollment, generated flat results that contradict the existing body of knowledge and has a primary efficacy endpoint confounded by a treatment-by-COVID interaction? Could it be a false negative finding?

Indexed as

BismuthDiarrheaOrganometallic CompoundsSalicylatesTravel-Related IllnessAntidiarrhealsClinical Trials, Phase III as TopicConfounding Factors, EpidemiologicCOVID-19HumansIncidenceRandomized Controlled Trials as TopicResearch DesignTreatment OutcomeAntidiarrhealsBismuthbismuth subsalicylateOrganometallic CompoundsSalicylatesBismuth subsalicylatetraveller’s diarrhoea

Identifiers

PMID40720752
PMCPMC12491659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.