ArticleNeurology2025
Features, Outcome, and Treatment of Postanoxic Status Epilepticus: Pooled Analysis of 3 Cohorts.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Dual Antiglutamate Therapy in Super-Refractory Status Epilepticus After Cardiac Arrest (SUPER-CAT Study).Neurology · 2026Observational
- Rhythmic and Periodic Patterns and Seizures in Hypoxic-Ischemic Encephalopathy.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026Review
- Role of Neurophysiologic Testing in Prognostication of Hypoxic-Ischemic Encephalopathy.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2026Review
- Utility in prognostication of continuous EEG monitoring in postanoxic coma: importance on timing in relation to the cardiac arrest.Critical care (London, England) · 2026Article
- Annual Course / From Then to Now: The Evolving Spectrum of Epilepsy Care.Epilepsy currents · 2025Article
- Features, Outcome, and Treatment of Postanoxic Status Epilepticus: Pooled Analysis of 3 Cohorts.Neurology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe prognostic significance and the benefits of antiseizure treatment for definite and possible status epilepticus (SE) after cardiac arrest (CA) remain debated. The study aims to identify clinical and EEG predictors of outcome in definite and possible SE after CA and to determine patient categories in which antiseizure medication is useful.
methodsWe conducted a multicenter pooled analysis of individual patient data from the Treatment of ELectroencephalographic STatus epilepticus After cardiopulmonary Resuscitation trial and 2 local registries (Brussels and Geneva). Patients with EEG patterns fulfilling the American Clinical Neurophysiology Society criteria for definite or possible SE within 72 hours after CA were included. Primary outcome was the cerebral performance category (CPC) at 3 months, dichotomized as good (CPC 1-2) or poor (CPC 3-5). Patients, clinical, EEG, and treatment characteristics were related to outcome using univariate and multivariate analyses in the whole cohort and separate for patients without ≥2 poor outcome European Resuscitation Council (ERC)/European Society of Intensive Care Medicine (ESICM) criteria. This latter group of patients was further divided into 2 subgroups: those with definite SE and those with possible SE.
resultsOf 274 patients (median age 66 [interquartile range (IQR) 55-75], 31% female) with definite or possible SE, 24 (8.8%) had good recovery. In multivariate analysis, nonmotor semiology and SE cessation were associated with good recovery. After exclusion of patients with ≥2 poor outcome ERC/ESICM criteria (180 patients), we included 94 patients (52 definite SE and 42 possible SE), 25% having good outcome. In definite SE, SE cessation (12 [100%] vs 20 [50%], DISCUSSION: Patients with postanoxic definite or possible SE have a 25% chance of good outcome in the absence of ≥2 poor outcome ERC/ESICM factors. EEG background continuity before SE onset and higher discharge frequency contribute to the identification of patients who may benefit from protracted treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.