Evidence map›Paper›PMID 40720649›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Early-life human CD8

Nina N Brodsky, Monisha Chakder, Dinesh Babu Uthaya Kumar, Anis Barmada, Julia Wang, Weihong Gu, Oluwabunmi Olaloye, Anjali Ramaswamy, Aanchal Wats, Liza Konnikova and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Immune development in early life.Nature immunology · 2026
    Review
  3. Review
  4. Article
  5. FcεRγI promotes canine CD8 chimeric antigen receptor T cell cytotoxicity through a Syk-NF-κB axis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nina N BrodskyPediatrics Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0003-2472-7397
Monisha ChakderPediatrics Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0009-0003-7188-7243
Dinesh Babu Uthaya KumarImmunobiology Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0001-7210-5811
Anis BarmadaImmunobiology Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-8259-2892
Julia WangYale University, New Haven, CT 06520.ORCID 0009-0000-4583-6686
Weihong GuPediatrics Department, Yale University School of Medicine, New Haven, CT 06520.
Oluwabunmi OlaloyePediatrics Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-9217-3333
Anjali RamaswamyImmunobiology Department, Yale University School of Medicine, New Haven, CT 06520.
Aanchal WatsPediatrics Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-2706-9660
Liza KonnikovaPediatrics Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0003-4804-5497
Carrie L LucasImmunobiology Department, Yale University School of Medicine, New Haven, CT 06520.ORCID 0000-0002-5754-0820

Funding

Medical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M
Function of T cells at the Maternal-Fetal InterfaceR01AI171980 · NIAID · YALE UNIVERSITY · PI Liza Konnikova · 2022 to 2026
$3.5M
PI3K signaling in regulation of CD8 T cell senescence and deathR00HL125668 · NHLBI · YALE UNIVERSITY · PI LUCAS, CARRIE L. · 2016 to 2018
$745k
Targetable pathways driving sub-optimal early-life CD8 T cell responsesK08AI177743 · NIAID · YALE UNIVERSITY · PI Nina Brodsky · 2024 to 2026
$585k
Peripheral Immune Development in Premature Infants with and without NECR21HD102565 · NICHD · YALE UNIVERSITY · PI KONNIKOVA, LIZA, TSENG, GEORGE C. · 2020 to 2021
$456k
HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID) MultipleNHLBI NIH HHS R00 HL125668NIAID NIH HHS K08 AI177743NIAID NIH HHS R01 AI171980NICHD NIH HHS R21 HD102565NIGMS NIH HHS T32 GM136651Yale University (Yale) N/A
6 · The paper itself

Abstract

Neonates and infants are distinct in their clinical and cellular responses to viral infections, with neonatal CD8

Indexed as

CD8-Positive T-LymphocytesTranscription FactorsFemaleHumansInfantInfant, NewbornTranscription FactorsCD8+ T celldifferentiationeffectorneonatetranscription factor

Identifiers

PMID40720649
PMCPMC12337316

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.