ArticleMagnetic resonance in medicine2025
Time-resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cardiovascular Magnetic Resonance Elastography: Current Evidence, Challenges, and Future Perspectives.Diagnostics (Basel, Switzerland) · 2026Review
- Free-Breathing, 3D Cardiac Magnetic Resonance Elastography for Myocardial Stiffness Mapping.Magnetic resonance in medicine · 2026Article
- Time-resolved mapping of myocardial stiffness using 2D multifrequency spiral MR elastography with and without external vibration.Magnetic resonance in medicine · 2025Article
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Authors and funding
15 authors.
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Abstract
purposeThere is a clinical need for stiffness mapping of the heart; however, current cardiac magnetic resonance elastography (cMRE) has limited spatiotemporal resolution. Therefore, we developed 2D spiral multifrequency MRE of the human heart and conducted a study to analyze the consistency and reproducibility of motion-encoding and stiffness mapping with and without external vibration.
methodsEleven healthy volunteers were studied using single-slice gradient-echo spiral cMRE with cardiac triggering and encoding of harmonic shear wave fields at 70, 80, and 90 Hz frequency generated by either external drivers or endogenous heart motion. Tissue displacement was monitored synchronized to the cardiac cycle, and frequency-resolved shear wave speed (SWS) maps were reconstructed as a proxy for left ventricular (LV) stiffness variations. After several days, all subjects underwent repeat scanning for reproducibility analysis based on intraclass correlation coefficients (ICCs).
resultscMRE with external vibration showed LV SWS to be highest in end-systole (ES) (2.17 ± 0.23 m/s), followed by diastole (DIA) (1.94 ± 0.15 m/s) and isovolumetric contraction (IVC) (1.78 ± 0.18 m/s). ICCs decreased with distance from the R-wave from excellent (0.93) in IVC to moderate (0.68) in ES. Without external vibration, sufficient LV harmonic displacement amplitudes permitted SWS reconstruction, resulting in similar SWS, but lower ICC values than with external vibration in IVC and ES.
conclusionsMultifrequency cMRE offers high spatiotemporal resolution and reproducibility with external vibration. In addition, the technique allows the encoding of endogenous shear waves during cardiac phases with pronounced wall motion.
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